Lead intoxication-induced exosomes promote autophagy and apoptosis in renal proximal tubule cells by activating the adenosine 5'-monophosphate-activated protein kinase signaling.

Jiang, Qian; Feng, Xuefang; Shen, Jie; Wang, Yanan; Zhang, Yinghui; Zhou, Rong

Jiang, Qian; Feng, Xuefang; Shen, Jie; Wang, Yanan; Zhang, Yinghui; Zhou, Rong.

Afiliação

Jiang Q; Department of Nephrology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China.
Feng X; Department of Nephrology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China.
Shen J; Department of Nephrology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China.
Wang Y; Department of Nephrology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China.
Zhang Y; Department of Nephrology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China.
Zhou R; Department of Nephrology, Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China.

Environ Toxicol ; 38(5): 1011-1021, 2023 May.

Article em En | MEDLINE | ID: mdl-36840722

Assuntos

Exossomos; Chumbo; Camundongos; Animais; Chumbo/toxicidade; Proteínas Quinases Ativadas por AMP/genética; Proteínas Quinases Ativadas por AMP/metabolismo; Túbulos Renais Proximais/metabolismo; Autofagia; Apoptose; Adenosina/metabolismo

Palavras-chave

AMPK signaling; apoptosis; autophagy; exosome; lead intoxication

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Exossomos / Chumbo Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Exossomos / Chumbo Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article