Optimizing selection of in vitro tests for diagnosing thyroid disorders.
Nucl Med Commun
; 8(9): 759-65, 1987 Sep.
Article
em En
| MEDLINE
| ID: mdl-3684111
ABSTRACT
The optimal utilization of the thyroid related radioimmunoassays T3, T4, and TSH-RIA is derived from analysing the clinical and laboratory data for 974 patients with functional thyroid disorders. A statistical computer analysis of the contribution of each of the three tests, and in combination, to the final diagnoses of hypothyroid, euthyroid, and hyper thyroid states was designed. The best contributing test for hypothyroidism and euthyroidism was TSH-RIA (98.5 and 93%, respectively). T4/T3 + TSH-RIAs were the optimal dual combination for diagnosing euthyroidism (98.0%). For diagnosing hyperthyroidism T4-RIA was the best single test (82.5%) followed by T3 + T4 as an optimal dual combination (95%). Using all three tests was of no significant additional value over dual combinations. It is concluded that the work and cost of randomly performing three tests routinely is not justified without clinical basis. An algorithm is proposed to guide thyroid studies based on computer analyses of the above-mentioned single or dual-test combinations to establish accurate diagnosis at the lowest laboratory cost.
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Base de dados:
MEDLINE
Assunto principal:
Doenças da Glândula Tireoide
/
Tiroxina
/
Tri-Iodotironina
/
Tireotropina
Tipo de estudo:
Diagnostic_studies
Limite:
Female
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1987
Tipo de documento:
Article