The Role of Substance P, Neurokinin A, Neuropeptide Y, and Cortisol in Assessing Neonatal Pain.
Neonatal Netw
; 42(2): 65-71, 2023 Mar 01.
Article
em En
| MEDLINE
| ID: mdl-36868802
ABSTRACT
Introduction:
Our aim was to investigate biomarkers of neonatal pain and their association with two pain scales.Methods:
This prospective study included 54 full-term neonates. Levels of substance P (SubP), neurokinin A (NKA), neuropeptide Y (NPY), and cortisol were recorded and two pain scales (Premature Infant Pain Profile [PIPP] and Neonatal Infant Pain Scale [NIPS]) were used.Results:
A statistically significant decrease in the levels of NPY (p = 0.02) and NKA (p = 0.03) was detected. A significant increase in NIPS scale (p < 0.001) and PIPP scale (p < 0.001) postpainful intervention was also detected. There was a positive correlation between cortisol and SubP (p = 0.01), NKA and NPY (p < 0.001) and between NIPS and PIPP (p < 0.001). A negative correlation was found for NPY with SubP (p = 0.004), cortisol (p = 0.02), NIPS (p = 0.001) and PIPP (p = 0.002).Conclusions:
Novel biomarkers and pain scales may help in designing an objective tool for the quantification of neonatal pain in the everyday practice.Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neuropeptídeo Y
/
Substância P
Tipo de estudo:
Observational_studies
/
Risk_factors_studies
Limite:
Humans
/
Infant
/
Newborn
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article