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The IPDGC/GP2 Hackathon - an open science event for training in data science, genomics, and collaboration using Parkinson's disease data.
Leonard, Hampton L; Murtadha, Ruqaya; Martinez-Carrasco, Alejandro; Jama, Alina; Müller-Nedebock, Amica Corda; Gil-Martinez, Ana-Luisa; Illarionova, Anastasia; Moore, Anni; Bustos, Bernabe I; Jadhav, Bharati; Huxford, Brook; Storm, Catherine; Towns, Clodagh; Vitale, Dan; Chetty, Devina; Yu, Eric; Grenn, Francis P; Salazar, Gabriela; Rateau, Geoffrey; Iwaki, Hirotaka; Elsayed, Inas; Foote, Isabelle Francesca; Jansen van Rensburg, Zuné; Kim, Jonggeol Jeff; Yuan, Jie; Lake, Julie; Brolin, Kajsa; Senkevich, Konstantin; Wu, Lesley; Tan, Manuela M X; Periñán, María Teresa; Makarious, Mary B; Ta, Michael; Pillay, Nikita Simone; Betancor, Oswaldo Lorenzo; Reyes-Pérez, Paula R; Alvarez Jerez, Pilar; Saini, Prabhjyot; Al-Ouran, Rami; Sivakumar, Ramiya; Real, Raquel; Reynolds, Regina H; Hu, Ruifneg; Abrahams, Shameemah; Rao, Shilpa C; Antar, Tarek; Leal, Thiago Peixoto; Iankova, Vassilena; Scotton, William J; Song, Yeajin.
Afiliação
  • Leonard HL; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA. leonardhl@nih.gov.
  • Murtadha R; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. leonardhl@nih.gov.
  • Martinez-Carrasco A; Data Tecnica International LLC, Washington, DC, USA. leonardhl@nih.gov.
  • Jama A; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany. leonardhl@nih.gov.
  • Müller-Nedebock AC; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Gil-Martinez AL; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.
  • Illarionova A; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK.
  • Moore A; Division of Molecular Biology and Human Genetics, Department of Biomedical Sciences, Faculty of Medicine and Health Sciences, Stellenbosch University, Cape Town, South Africa.
  • Bustos BI; South African Medical Research Council/Stellenbosch University Genomics of Brain Disorders Research Unit, Stellenbosch University, Cape Town, South Africa.
  • Jadhav B; Department of Neurodegenerative Disease, University College London, London, UK.
  • Huxford B; Great Ormond Street Institute of Child Health, Genetics and Genomic Medicine, University College London, London, UK.
  • Storm C; German Center for Neurodegenerative Diseases (DZNE), Tübingen, Germany.
  • Towns C; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
  • Vitale D; The Ken & Ruth Davee Department of Neurology and Simpson Querrey Center of Neurogenetics, Feinberg Feinberg School of Medicine, Northwestern University, Chicago, IL, 60611, USA.
  • Chetty D; Department of Genetics and Genomic Sciences and Mindich Child Health and Development Institute, Icahn School of Medicine at Mount, Hess Center for Science and Medicine, New York, NY, 10029, USA.
  • Yu E; Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
  • Grenn FP; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.
  • Salazar G; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.
  • Rateau G; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
  • Iwaki H; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Elsayed I; Data Tecnica International LLC, Washington, DC, USA.
  • Foote IF; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK.
  • Jansen van Rensburg Z; Department of Human Genetics, McGill University, Montreal, QC, Canada.
  • Kim JJ; The Neuro (Montreal Neurological Institute-Hospital), McGill University, Montreal, QC, Canada.
  • Yuan J; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
  • Lake J; INNCOSYS, Col. Morelos Second Section, 50120, Toluca de Lerdo, México.
  • Brolin K; Institut du Cerveau - Institute of Brain and Spine (ICM), Hôpital Pitié, 47 Bd de l'Hôpital, 75013, Paris, France.
  • Senkevich K; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
  • Wu L; Center for Alzheimer's and Related Dementias (CARD), National Institute on Aging and National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
  • Tan MMX; Data Tecnica International LLC, Washington, DC, USA.
  • Periñán MT; Faculty of pharmacy, University of Gezira, Wad Medani, P.O. Box 20, Sudan.
  • Makarious MB; International Parkinson Disease Genomics Consortium (IPDGC)-Africa, University of Gezira, Wad Medani, P.O. Box 20, Sudan.
  • Ta M; Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
  • Pillay NS; Unit for Psychological Medicine, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
  • Betancor OL; Department of Neuromuscular Diseases, UCL Queen Square Institute of Neurology, University College London, London, UK.
  • Reyes-Pérez PR; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
  • Alvarez Jerez P; Preventive Neurology Unit, Wolfson Institute of Population Health, Queen Mary University of London, London, UK.
  • Saini P; Center for Advanced Parkinson Research, Brigham and Women's Hospital, Harvard Medical School, Boston, MA, 02115, USA.
  • Al-Ouran R; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
  • Sivakumar R; Translational Neurogenetics Unit, Wallenberg Neuroscience Center, Department of Experimental Medical Science, Lund University, Lund, Sweden.
  • Real R; Department of Human Genetics, McGill University, Montreal, QC, Canada.
  • Reynolds RH; Department of Neurology and Neurosurgery, McGill University, Montréal, QC, Canada.
  • Hu R; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.
  • Abrahams S; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.
  • Rao SC; Department of Neurology, Oslo University Hospital, Oslo, Norway.
  • Antar T; Unidad de Trastornos del Movimiento, Servicio de Neurología y Neurofisiología Clínica, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, Spain.
  • Leal TP; CIBERNED, Madrid, Spain.
  • Iankova V; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
  • Scotton WJ; Department of Clinical and Movement Neurosciences, UCL Queen Square Institute of Neurology, University College London, London, UK.
  • Song Y; Laboratory of Neurogenetics, National Institute on Aging, National Institutes of Health, Bethesda, MD, USA.
NPJ Parkinsons Dis ; 9(1): 33, 2023 Mar 04.
Article em En | MEDLINE | ID: mdl-36871034
ABSTRACT
Open science and collaboration are necessary to facilitate the advancement of Parkinson's disease (PD) research. Hackathons are collaborative events that bring together people with different skill sets and backgrounds to generate resources and creative solutions to problems. These events can be used as training and networking opportunities, thus we coordinated a virtual 3-day hackathon event, during which 49 early-career scientists from 12 countries built tools and pipelines with a focus on PD. Resources were created with the goal of helping scientists accelerate their own research by having access to the necessary code and tools. Each team was allocated one of nine different projects, each with a different goal. These included developing post-genome-wide association studies (GWAS) analysis pipelines, downstream analysis of genetic variation pipelines, and various visualization tools. Hackathons are a valuable approach to inspire creative thinking, supplement training in data science, and foster collaborative scientific relationships, which are foundational practices for early-career researchers. The resources generated can be used to accelerate research on the genetics of PD.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article