Cell Encapsulation and 3D Bioprinting for Therapeutic Cell Transplantation.
ACS Biomater Sci Eng
; 9(4): 1862-1890, 2023 04 10.
Article
em En
| MEDLINE
| ID: mdl-36877212
ABSTRACT
The promise of cell therapy has been augmented by introducing biomaterials, where intricate scaffold shapes are fabricated to accommodate the cells within. In this review, we first discuss cell encapsulation and the promising potential of biomaterials to overcome challenges associated with cell therapy, particularly cellular function and longevity. More specifically, cell therapies in the context of autoimmune disorders, neurodegenerative diseases, and cancer are reviewed from the perspectives of preclinical findings as well as available clinical data. Next, techniques to fabricate cell-biomaterials constructs, focusing on emerging 3D bioprinting technologies, will be reviewed. 3D bioprinting is an advancing field that enables fabricating complex, interconnected, and consistent cell-based constructs capable of scaling up highly reproducible cell-biomaterials platforms with high precision. It is expected that 3D bioprinting devices will expand and become more precise, scalable, and appropriate for clinical manufacturing. Rather than one printer fits all, seeing more application-specific printer types, such as a bioprinter for bone tissue fabrication, which would be different from a bioprinter for skin tissue fabrication, is anticipated in the future.
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Base de dados:
MEDLINE
Assunto principal:
Engenharia Tecidual
/
Bioimpressão
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article