IP-LC-MSMS Enables Identification of Three Tau <i>O</i>-GlcNAcylation Sites as <i>O</i>-GlcNAcase Inhibition Pharmacodynamic Readout in Transgenic Mice Overexpressing Human Tau.

Bijttebier, Sebastiaan; Rodrigues Martins, Dina; Mertens, Liesbeth; Grauwen, Karolien; Bruinzeel, Wouter; Willems, Roland; Bartolomé-Nebreda, José Manuel; Theunis, Clara; Bretteville, Alexis; Ebneth, Andreas; Dillen, Lieve

IP-LC-MSMS Enables Identification of Three Tau O-GlcNAcylation Sites as O-GlcNAcase Inhibition Pharmacodynamic Readout in Transgenic Mice Overexpressing Human Tau.

Bijttebier, Sebastiaan; Rodrigues Martins, Dina; Mertens, Liesbeth; Grauwen, Karolien; Bruinzeel, Wouter; Willems, Roland; Bartolomé-Nebreda, José Manuel; Theunis, Clara; Bretteville, Alexis; Ebneth, Andreas; Dillen, Lieve.

Afiliação

Bijttebier S; Bioanalytical Discovery & Development Sciences, Janssen R&D, Turnhoutseweg 30, 2340 Beerse, Belgium.
Rodrigues Martins D; R&D Neurosciences, Janssen R&D, Turnhoutseweg 30, 2340 Beerse, Belgium.
Mertens L; R&D Neurosciences, Janssen R&D, Turnhoutseweg 30, 2340 Beerse, Belgium.
Grauwen K; R&D Neurosciences, Janssen R&D, Turnhoutseweg 30, 2340 Beerse, Belgium.
Bruinzeel W; R&D Structural & Protein Sciences, Janssen R&D, Turnhoutseweg 30, 2340 Beerse, Belgium.
Willems R; R&D Neurosciences, Janssen R&D, Turnhoutseweg 30, 2340 Beerse, Belgium.
Bartolomé-Nebreda JM; Global Discovery Chemistry, Janssen R&D, Jarama 75A, 45007 Toledo, Spain.
Theunis C; R&D Neurosciences, Janssen R&D, Turnhoutseweg 30, 2340 Beerse, Belgium.
Bretteville A; R&D Neurosciences, Janssen R&D, Turnhoutseweg 30, 2340 Beerse, Belgium.
Ebneth A; R&D Neurosciences, Janssen R&D, Turnhoutseweg 30, 2340 Beerse, Belgium.
Dillen L; Bioanalytical Discovery & Development Sciences, Janssen R&D, Turnhoutseweg 30, 2340 Beerse, Belgium.

J Proteome Res ; 22(4): 1309-1321, 2023 04 07.

Article em En | MEDLINE | ID: mdl-36888912

Assuntos

beta-N-Acetil-Hexosaminidases; Proteínas tau; Animais; Humanos; Camundongos; Acetilglucosamina/farmacologia; beta-N-Acetil-Hexosaminidases/genética; Camundongos Transgênicos; N-Acetilglucosaminiltransferases/genética; N-Acetilglucosaminiltransferases/metabolismo; Fosforilação; Proteínas tau/química; Espectrometria de Massas em Tandem

Palavras-chave

Alzheimer's disease; IP-LC-MSMS; O-GlcNAc hydrolase inhibition; P301S transgenic mouse brain homogenates; tau O-GlcNAcylation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Beta-N-Acetil-Hexosaminidases / Proteínas tau Tipo de estudo: Diagnostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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