Your browser doesn't support javascript.
loading
Melatonin protects against methotrexate hepatotoxicity in young rats: Impact of PI3K/Akt/mTOR signaling.
Wang, Su-Chen; Huang, Yi-Chuan; Hsiao, Chih-Cheng; Sheen, Jiunn-Ming; Huang, Li-Tung; Lo, Wan-Shan; Hsieh, Hsin-Yi; Chen, Yu-Chieh.
Afiliação
  • Wang SC; Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
  • Huang YC; Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
  • Hsiao CC; Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
  • Sheen JM; Department of Traditional Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Huang LT; Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
  • Lo WS; Department of Traditional Medicine, Chang Gung University, Taoyuan, Taiwan.
  • Hsieh HY; Department of Pediatrics, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan.
  • Chen YC; Department of Traditional Medicine, Chang Gung University, Taoyuan, Taiwan.
J Biochem Mol Toxicol ; 37(5): e23323, 2023 May.
Article em En | MEDLINE | ID: mdl-36890697
ABSTRACT
With the improvement in children's acute lymphoblastic leukemia (ALL) care, the survival rate in children ALL has improved much. Methotrexate (MTX) plays an essential role in the success of children's ALL treatment. Since hepatotoxicity is commonly reported in individuals treated with intravenous or oral MTX, our study further examined the hepatic effect following intrathecal MTX treatment, which is an essential treatment for leukemia patients. Specifically, we examined the pathogenesis of MTX hepatotoxicity in young rats and explored the impact of melatonin treatment in protection against MTX hepatotoxicity. Successfully, we found that melatonin was able to protect against MTX hepatotoxicity.
Assuntos
Palavras-chave
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras / Doença Hepática Induzida por Substâncias e Drogas / Melatonina Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras / Doença Hepática Induzida por Substâncias e Drogas / Melatonina Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article