Glomerella fusarioides-catalyzed structural transformation of steroidal drugs mesterolone and methasterone, and anti-inflammatory activity of resulting derivatives.

Aziz, Ambreen; Siddiqui, Mahwish; Khan, Nisha; Jabeen, Almas; Ahmed, Zaheer; Iqbal Choudhary, M

Aziz, Ambreen; Siddiqui, Mahwish; Khan, Nisha; Jabeen, Almas; Ahmed, Zaheer; Iqbal Choudhary, M.

Afiliação

Aziz A; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Atia-Tul-Wahab; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan. Electronic address: atia.tulwahab@iccs.edu.
Siddiqui M; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Khan N; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Jabeen A; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Ahmed Z; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan.
Iqbal Choudhary M; H. E. J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences, University of Karachi, Karachi 75270, Pakistan; Dr. Panjwani Center for Molecular Medicine and Drug Research, International Center for Chemical and Biological Sciences, University of Karachi, Karachi

Steroids ; 194: 109219, 2023 06.

Article em En | MEDLINE | ID: mdl-36893829

Assuntos

Mesterolona; Phyllachorales; Congêneres da Testosterona; Humanos; Anti-Inflamatórios/farmacologia; Catálise; Espectroscopia de Ressonância Magnética; Mesterolona/química; Mesterolona/metabolismo; Phyllachorales/metabolismo; Congêneres da Testosterona/química; Congêneres da Testosterona/metabolismo

Palavras-chave

Anti-inflammatory; Biotransformation; Mesterolone; Methasterone; NÈ® Inhibition

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Phyllachorales / Congêneres da Testosterona / Mesterolona Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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