Reframing Optimal Control Problems for Infectious Disease Management in Low-Income Countries.
Bull Math Biol
; 85(4): 31, 2023 03 12.
Article
em En
| MEDLINE
| ID: mdl-36907932
ABSTRACT
Optimal control theory can be a useful tool to identify the best strategies for the management of infectious diseases. In most of the applications to disease control with ordinary differential equations, the objective functional to be optimized is formulated in monetary terms as the sum of intervention costs and the cost associated with the burden of disease. We present alternate formulations that express epidemiological outcomes via health metrics and reframe the problem to include features such as budget constraints and epidemiological targets. These alternate formulations are illustrated with a compartmental cholera model. The alternate formulations permit us to better explore the sensitivity of the optimal control solutions to changes in available budget or the desired epidemiological target. We also discuss some limitations of comprehensive cost assessment in epidemiology.
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Base de dados:
MEDLINE
Assunto principal:
Infecções
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article