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Immunophenotypic profiles and prognosis for colorectal mucinous adenocarcinomas are dependent on anatomic location.
Patel, Chirag; Behring, Michael; Al Diffalha, Sameer; Dhall, Deepti; Lee, Goo; Shanmugam, Chandrakumar; Grizzle, William E; Manne, Upender.
Afiliação
  • Patel C; Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Behring M; Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Al Diffalha S; Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Dhall D; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Lee G; Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Shanmugam C; O'Neal Comprehensive Cancer Center, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Grizzle WE; Department of Pathology, University of Alabama at Birmingham, Birmingham, Alabama, USA.
  • Manne U; Department of Pathology, RVM Institute of Medical Sciences & Research Center, KNR University of Health Sciences, Siddipet, India.
Cancer Med ; 12(8): 9637-9643, 2023 04.
Article em En | MEDLINE | ID: mdl-36916704
BACKGROUND: The prognostic value of mucinous adenocarcinomas (MCAs, exhibiting >50% extracellular mucin) of the colorectum, in relation to their anatomic location is not well studied. MATERIALS AND METHODS: We compared MCAs (n = 175) with non-MCAs (NMCAs, n = 1015) and the cancer-specific survival rates were evaluated, based on their anatomic site, by univariate Kaplan-Meier and multivariate Cox methods. Subsets of these tumors were immunostained for MUC1, MUC2, Bcl-2, and p53. RESULTS: MCAs were more commonly found in the right colon, were of high-grade, and were more prevalent in younger patients (<40 years). They exhibited strong expression of MUC2 and Bcl-2 and showed less p53 nuclear staining. In contrast, most NMCAs were low-grade with high expression of MUC1. MCAs of the rectum were associated with poorer outcomes relative to NMCAs (HR 1.85, CI 95% 1.15-2.97), even though the distributions of advanced-stage tumors were similar. CONCLUSION: Late-stage disease and age were poor independent prognostic indicators of cancer-specific deaths across all tumor locations. In summary, rectal MCAs have a poor prognosis.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Adenocarcinoma Mucinoso Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Colorretais / Adenocarcinoma Mucinoso Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article