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A NIR fluorescent probe for dual imaging of mitochondrial viscosity and FA in living cells and zebrafish.
Liang, Feng; Huang, Wanyun; Wu, Lei; Wu, Yihong; Zhang, Tingrui; He, Xiaolong; Wang, Zhouyu; Yu, Xiaoqi; Li, Yuzhi; Qian, Shan.
Afiliação
  • Liang F; Department of Pharmaceutical Engineering, College of Food and Bioengineering, Xihua University, Chengdu 610039, China. qians@mail.xhu.edu.cn.
  • Huang W; Department of Pharmaceutical Engineering, College of Food and Bioengineering, Xihua University, Chengdu 610039, China. qians@mail.xhu.edu.cn.
  • Wu L; Department of Pharmaceutical Engineering, College of Food and Bioengineering, Xihua University, Chengdu 610039, China. qians@mail.xhu.edu.cn.
  • Wu Y; Department of Pharmaceutical Engineering, College of Food and Bioengineering, Xihua University, Chengdu 610039, China. qians@mail.xhu.edu.cn.
  • Zhang T; State Key Laboratory of Southwestern Chinese Medicine Resources, Pharmacy College, Chengdu 610091, China.
  • He X; Department of Pharmaceutical Engineering, College of Food and Bioengineering, Xihua University, Chengdu 610039, China. qians@mail.xhu.edu.cn.
  • Wang Z; Asymmetric Synthesis and Chiral Technology Key Laboratory of Sichuan Province, Research and Application of Small Organic Chiral Molecules Key Laboratory of Yibin City, China.
  • Yu X; Asymmetric Synthesis and Chiral Technology Key Laboratory of Sichuan Province, Research and Application of Small Organic Chiral Molecules Key Laboratory of Yibin City, China.
  • Li Y; Department of Pharmaceutical Engineering, College of Food and Bioengineering, Xihua University, Chengdu 610039, China. qians@mail.xhu.edu.cn.
  • Qian S; Asymmetric Synthesis and Chiral Technology Key Laboratory of Sichuan Province, Research and Application of Small Organic Chiral Molecules Key Laboratory of Yibin City, China.
Analyst ; 148(7): 1437-1441, 2023 Mar 27.
Article em En | MEDLINE | ID: mdl-36919562
ABSTRACT
Formaldehyde (FA) and viscosity play multiple roles in human health and diseases, and viscosity has great regional differences due to the diversity of subcellular organelles. However, it is challenging to achieve dual detection of viscosity and FA in subcellular organelles. Herein, we developed a near infrared (NIR) fluorescent probe FA-Cy, which can simultaneously monitor the viscosity and FA concentration of mitochondria in living cells. The probe could detect mitochondrial viscosity and exogenous and endogenous FA in living cells and zebrafish.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peixe-Zebra / Corantes Fluorescentes Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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XML
PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Peixe-Zebra / Corantes Fluorescentes Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article