Design and biological evaluation of Repaglinide loaded polymeric nanocarriers for diabetes linked neurodegenerative disorder: QbD-driven optimization, in situ, in vitro and in vivo investigation.

Wadhwa, Geetika; Venkata Krishna, Kowthavarapu; Kumar Dubey, Sunil; Taliyan, Rajeev

Wadhwa, Geetika; Venkata Krishna, Kowthavarapu; Kumar Dubey, Sunil; Taliyan, Rajeev.

Afiliação

Wadhwa G; Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Pilani Campus, Rajasthan 333031, India.
Venkata Krishna K; Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Pilani Campus, Rajasthan 333031, India; Center for Pharmacometrics and Systems Pharmacology, Department of Pharmaceutics, College of Pharmacy, University of Florida, Orlando, FL 32827, USA.
Kumar Dubey S; Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Pilani Campus, Rajasthan 333031, India; Medical Research, R&D Healthcare Division, Emami Ltd, 13, BT Road, Belgharia, Kolkata 700056, India.
Taliyan R; Department of Pharmacy, Birla Institute of Technology and Science, Pilani, Pilani Campus, Rajasthan 333031, India. Electronic address: rajeev.taliyan@pilani.bits-pilani.ac.in.

Int J Pharm ; 636: 122824, 2023 Apr 05.

Article em En | MEDLINE | ID: mdl-36921745

Assuntos

Diabetes Mellitus; Nanopartículas; Doenças Neurodegenerativas; Camundongos; Humanos; Animais; Portadores de Fármacos/química; Distribuição Tecidual; Polímeros/química; Nanopartículas/química; Tamanho da Partícula

Palavras-chave

Behavioral parameters; Diabetes; High-fat diet streptozotocin model; Neurodegeneration; PEG-PCL; Polymeric nanoparticles; Repaglinide; SPIP

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Doenças Neurodegenerativas / Diabetes Mellitus / Nanopartículas Tipo de estudo: Prognostic_studies Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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