The role of O-GlcNAcylation in development.
Development
; 150(6)2023 03 15.
Article
em En
| MEDLINE
| ID: mdl-36924340
ABSTRACT
O-GlcNAcylation is a dynamic post-translational modification performed by two opposing enzymes O-GlcNAc transferase and O-GlcNAcase. O-GlcNAcylation is generally believed to act as a metabolic integrator in numerous signalling pathways. The stoichiometry of this modification is tightly controlled throughout all stages of development, with both hypo/hyper O-GlcNAcylation resulting in broad defects. In this Primer, we discuss the role of O-GlcNAcylation in developmental processes from stem cell maintenance and differentiation to cell and tissue morphogenesis.
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Base de dados:
MEDLINE
Assunto principal:
Células-Tronco
/
Processamento de Proteína Pós-Traducional
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article