Optimization of triazolo[4,5-d]pyrimidines towards human CC chemokine receptor 7 (CCR7) antagonists.

Van Hoof, Max; Claes, Sandra; Proj, Matic; Van Loy, Tom; Schols, Dominique; Gobec, Stanislav; Dehaen, Wim; De Jonghe, Steven

Van Hoof, Max; Claes, Sandra; Proj, Matic; Van Loy, Tom; Schols, Dominique; Gobec, Stanislav; Dehaen, Wim; De Jonghe, Steven.

Afiliação

Van Hoof M; Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, B-3001, Leuven, Belgium.
Claes S; KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Herestraat 49, box 1043, 3000, Leuven, Belgium.
Proj M; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000, Ljubljana, Slovenia.
Van Loy T; KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Herestraat 49, box 1043, 3000, Leuven, Belgium.
Schols D; KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Herestraat 49, box 1043, 3000, Leuven, Belgium.
Gobec S; Department of Pharmaceutical Chemistry, Faculty of Pharmacy, University of Ljubljana, Askerceva 7, 1000, Ljubljana, Slovenia.
Dehaen W; Molecular Design and Synthesis, Department of Chemistry, KU Leuven, Celestijnenlaan 200F, B-3001, Leuven, Belgium.
De Jonghe S; KU Leuven, Department of Microbiology, Immunology and Transplantation, Rega Institute for Medical Research, Laboratory of Virology and Chemotherapy, Herestraat 49, box 1043, 3000, Leuven, Belgium. Electronic address: steven.dejonghe@kuleuven.be.

Eur J Med Chem ; 251: 115240, 2023 May 05.

Article em En | MEDLINE | ID: mdl-36924670

Assuntos

Receptores Acoplados a Proteínas G; Transdução de Sinais; Humanos; Receptores CCR7/metabolismo; Simulação de Acoplamento Molecular; Relação Estrutura-Atividade; Pirimidinas/farmacologia; Pirimidinas/química

Palavras-chave

1,2,3-triazolo[4,5-d]pyrimidine; CCR7 antagonist; CXCR2 antagonist; Hit finding; SAR optimization

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transdução de Sinais / Receptores Acoplados a Proteínas G Tipo de estudo: Prognostic_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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