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Comparative genomics reveals the diversification of triterpenoid biosynthesis and origin of ocotillol-type triterpenes in Panax.
Yang, Zijiang; Li, Xiaobo; Yang, Ling; Peng, Sufang; Song, Wanling; Lin, Yuan; Xiang, Guisheng; Li, Ying; Ye, Shuang; Ma, Chunhua; Miao, Jianhua; Zhang, Guanghui; Chen, Wei; Yang, Shengchao; Dong, Yang.
Afiliação
  • Yang Z; National & Local Joint Engineering Research Center on Germplasm Innovation & Utilization of Chinese Medicinal Materials in Southwest China, Yunnan Agricultural University, Kunming, China; The Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural University, Kunmin
  • Li X; National & Local Joint Engineering Research Center on Germplasm Innovation & Utilization of Chinese Medicinal Materials in Southwest China, Yunnan Agricultural University, Kunming, China; The Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural University, Kunmin
  • Yang L; National & Local Joint Engineering Research Center on Germplasm Innovation & Utilization of Chinese Medicinal Materials in Southwest China, Yunnan Agricultural University, Kunming, China; College of Food Science and Technology, Yunnan Agricultural University, Kunming, China.
  • Peng S; National & Local Joint Engineering Research Center on Germplasm Innovation & Utilization of Chinese Medicinal Materials in Southwest China, Yunnan Agricultural University, Kunming, China; The Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural University, Kunmin
  • Song W; National & Local Joint Engineering Research Center on Germplasm Innovation & Utilization of Chinese Medicinal Materials in Southwest China, Yunnan Agricultural University, Kunming, China; The Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural University, Kunmin
  • Lin Y; National & Local Joint Engineering Research Center on Germplasm Innovation & Utilization of Chinese Medicinal Materials in Southwest China, Yunnan Agricultural University, Kunming, China; The Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural University, Kunmin
  • Xiang G; National & Local Joint Engineering Research Center on Germplasm Innovation & Utilization of Chinese Medicinal Materials in Southwest China, Yunnan Agricultural University, Kunming, China; The Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural University, Kunmin
  • Li Y; National & Local Joint Engineering Research Center on Germplasm Innovation & Utilization of Chinese Medicinal Materials in Southwest China, Yunnan Agricultural University, Kunming, China; The Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural University, Kunmin
  • Ye S; National & Local Joint Engineering Research Center on Germplasm Innovation & Utilization of Chinese Medicinal Materials in Southwest China, Yunnan Agricultural University, Kunming, China; The Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural University, Kunmin
  • Ma C; National & Local Joint Engineering Research Center on Germplasm Innovation & Utilization of Chinese Medicinal Materials in Southwest China, Yunnan Agricultural University, Kunming, China; The Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural University, Kunmin
  • Miao J; Guangxi Key Laboratory of Medicinal Resources Protection and Genetic Improvement, Guangxi Botanical Garden of Medicinal Plants, Nanning, China.
  • Zhang G; National & Local Joint Engineering Research Center on Germplasm Innovation & Utilization of Chinese Medicinal Materials in Southwest China, Yunnan Agricultural University, Kunming, China; The Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural University, Kunmin
  • Chen W; National & Local Joint Engineering Research Center on Germplasm Innovation & Utilization of Chinese Medicinal Materials in Southwest China, Yunnan Agricultural University, Kunming, China; Guangxi Key Laboratory of Medicinal Resources Protection and Genetic Improvement, Guangxi Botanical Gard
  • Yang S; National & Local Joint Engineering Research Center on Germplasm Innovation & Utilization of Chinese Medicinal Materials in Southwest China, Yunnan Agricultural University, Kunming, China; The Key Laboratory of Medicinal Plant Biology of Yunnan Province, Yunnan Agricultural University, Kunmin
  • Dong Y; National & Local Joint Engineering Research Center on Germplasm Innovation & Utilization of Chinese Medicinal Materials in Southwest China, Yunnan Agricultural University, Kunming, China; Guangxi Key Laboratory of Medicinal Resources Protection and Genetic Improvement, Guangxi Botanical Gard
Plant Commun ; 4(4): 100591, 2023 07 10.
Article em En | MEDLINE | ID: mdl-36926697
ABSTRACT
Gene duplication is assumed to be the major force driving the evolution of metabolite biosynthesis in plants. Freed from functional burdens, duplicated genes can mutate toward novelties until fixed due to selective fitness. However, the extent to which this mechanism has driven the diversification of metabolite biosynthesis remains to be tested. Here we performed comparative genomics analysis and functional characterization to evaluate the impact of gene duplication on the evolution of triterpenoid biosynthesis using Panax species as models. We found that whole-genome duplications (WGDs) occurred independently in Araliaceae and Apiaceae lineages. Comparative genomics revealed the evolutionary trajectories of triterpenoid biosynthesis in plants, which was mainly promoted by WGDs and tandem duplication. Lanosterol synthase (LAS) was likely derived from a tandem duplicate of cycloartenol synthase that predated the emergence of Nymphaeales. Under episodic diversifying selection, the LAS gene duplicates produced by γ whole-genome triplication have given rise to triterpene biosynthesis in core eudicots through neofunctionalization. Moreover, functional characterization revealed that oxidosqualene cyclases (OSCs) responsible for synthesizing dammarane-type triterpenes in Panax species were also capable of producing ocotillol-type triterpenes. Genomic and biochemical evidence suggested that Panax genes encoding the above OSCs originated from the specialization of one OSC gene duplicate produced from a recent WGD shared by Araliaceae (Pg-ß). Our results reveal the crucial role of gene duplication in diversification of triterpenoid biosynthesis in plants and provide insight into the origin of ocotillol-type triterpenes in Panax species.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triterpenos / Ginsenosídeos / Panax Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Triterpenos / Ginsenosídeos / Panax Idioma: En Ano de publicação: 2023 Tipo de documento: Article