Dissolution Mechanisms of Amorphous Solid Dispersions: A Close Look at the Dissolution Interface.

Deac, Alexandru; Qi, Qingqing; Indulkar, Anura S; Gao, Yi; Zhang, Geoff G Z; Taylor, Lynne S

Deac, Alexandru; Qi, Qingqing; Indulkar, Anura S; Gao, Yi; Zhang, Geoff G Z; Taylor, Lynne S.

Afiliação

Deac A; Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States.
Qi Q; Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States.
Indulkar AS; Development Sciences, Research and Development, AbbVie Inc., North Chicago, Illinois 60064, United States.
Gao Y; Development Sciences, Research and Development, AbbVie Inc., North Chicago, Illinois 60064, United States.
Zhang GGZ; Development Sciences, Research and Development, AbbVie Inc., North Chicago, Illinois 60064, United States.
Taylor LS; Department of Industrial and Physical Pharmacy, College of Pharmacy, Purdue University, West Lafayette, Indiana 47907, United States.

Mol Pharm ; 20(4): 2217-2234, 2023 04 03.

Article em En | MEDLINE | ID: mdl-36926898

Assuntos

Polímeros; Compostos de Vinila; Solubilidade; Liberação Controlada de Fármacos; Compostos de Vinila/química; Preparações Farmacêuticas; Polímeros/química; Composição de Medicamentos/métodos

Palavras-chave

PVPVA; amorphous solid dispersion; confocal microscopy; copovidone; dissolution mechanism; fluorescent molecular probes; limit of congruency; phenolphthalein; water-induced phase separation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Polímeros / Compostos de Vinila Tipo de estudo: Prognostic_studies Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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