DNA sensing in the pathological process of ischemic stroke.
Eur J Neurosci
; 57(8): 1432-1441, 2023 04.
Article
em En
| MEDLINE
| ID: mdl-36932672
ABSTRACT
The innate immune response plays an important role in the pathological process of ischemic stroke. Increasing evidence suggests that the inflammatory response triggered by the innate immune system hinders neurological and behavioural recovery after stroke. The perception of abnormal DNA and its downstream effects are an essential part of the innate immune system. The abnormal DNA is the major inducing factor for innate immune response and is sensed by a series of DNA sensors. In this review, we discussed the multiple roles of DNA sensing in the pathological process of ischemic stroke, with a special focus on DNA sensors Toll-like receptor 9 (TLR9), absent in melanoma 2 (AIM2) and cyclic GMP-AMP synthase (cGAS).
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Base de dados:
MEDLINE
Assunto principal:
AVC Isquêmico
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article