Pauciflorins A-E, Unexpected Chromone-Monoterpene-Derived Meroterpenoids from Centrapalus pauciflorus.
J Nat Prod
; 86(4): 891-896, 2023 04 28.
Article
em En
| MEDLINE
| ID: mdl-36932959
Five unusual meroterpenoids based on new carbon skeletons, pauciflorins A-E (1-5), were isolated by multistep chromatographic separations of a methanol extract of the aerial parts of Centrapalus pauciflorus. Compounds 1-3 are derived by the connection of a 2-nor-chromone and a monoterpene unit, whereas 4 and 5 are dihydrochromone-monoterpene adducts with a rarely occurring orthoester functionality. The structures were solved using 1D and 2D NMR, HRESIMS, and single-crystal X-ray diffraction. Pauciflorins A-E were evaluated for antiproliferative activity against human gynecological cancer cell lines, but were inactive (IC50 < 10 µM) in each case.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Cromonas
/
Monoterpenos
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article