The p53/miR-29a-3p axis mediates the antifibrotic effect of leonurine on angiotensin II-stimulated rat cardiac fibroblasts.

Xi, Tianlan; Wang, Ruiyu; Pi, Damao; Ouyang, Jing; Yang, Jiadan

Xi, Tianlan; Wang, Ruiyu; Pi, Damao; Ouyang, Jing; Yang, Jiadan.

Afiliação

Xi T; Department of Pharmacy, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China; Institute of Life Science, Chongqing Medical University, Chongqing, China.
Wang R; Institute of Life Science, Chongqing Medical University, Chongqing, China.
Pi D; Department of Pharmacy, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Ouyang J; Clinical Research Center, Chongqing Public Health Medical Center, Chongqing, China. Electronic address: kejiaoke@cqgwzx.com.
Yang J; Department of Pharmacy, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China. Electronic address: 202632@hospital.cqmu.edu.cn.

Exp Cell Res ; 426(1): 113556, 2023 05 01.

Article em En | MEDLINE | ID: mdl-36933858

Assuntos

MicroRNAs; Ratos; Animais; Angiotensina II/farmacologia; Proteína Supressora de Tumor p53/genética; Proteína Supressora de Tumor p53/metabolismo; Fibrose; Colágeno Tipo I/metabolismo; Fibroblastos/metabolismo

Palavras-chave

Cardiac fibroblasts; Leonurine; Myocardial fibrosis; Rats; miR-29a-3p; p53

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: MicroRNAs Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: MicroRNAs Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article