p53 regulates the mitochondrial immune checkpoint.

Vanpouille-Box, Claire; Galluzzi, Lorenzo

Vanpouille-Box, Claire; Galluzzi, Lorenzo.

Afiliação

Vanpouille-Box C; Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA. Electronic address: clv2002@med.cornell.edu.
Galluzzi L; Department of Radiation Oncology, Weill Cornell Medical College, New York, NY, USA; Sandra and Edward Meyer Cancer Center, New York, NY, USA; Caryl and Israel Englander Institute for Precision Medicine, New York, NY, USA. Electronic address: deadoc80@gmail.com.

Trends Immunol ; 44(4): 245-247, 2023 04.

Article em En | MEDLINE | ID: mdl-36933950

ABSTRACT

ABSTRACT

Mitochondrial outer membrane permeabilization (MOMP) is crucial for the cytosolic accumulation of mitochondrial DNA (mtDNA) species that are required to jumpstart innate and adaptive immunity. Recent data reported by Ghosh et al. suggest that tumor protein p53 regulates MOMP-dependent type I interferon (IFN) production, not only via MOMP-promoting effects, but also by directing mtDNA-degrading exonucleases to proteasomal processing.

Assuntos

Mitocôndrias; Proteína Supressora de Tumor p53; Humanos; Proteína Supressora de Tumor p53/genética; Proteína Supressora de Tumor p53/metabolismo; Mitocôndrias/metabolismo; Apoptose; DNA Mitocondrial/genética

Palavras-chave

BAX; BCL2; DNA-damage response; TRIM24; apoptosis

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Proteína Supressora de Tumor p53 / Mitocôndrias Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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