Progress in the Total Synthesis of Antitumor Tetrahydroisoquinoline Alkaloids.
Chem Biodivers
; 20(5): e202300172, 2023 May.
Article
em En
| MEDLINE
| ID: mdl-36939065
ABSTRACT
Among the tetrahydroisoquinoline(THIQ) of natural products, a family of THIQ alkaloids has the characteristics of similar biosynthetic pathway. Such THIQ alkaloids family mainly include Renieramycins, Ecteinasicdins, Tetrazaomine, Lemonomycin, etc. Most of these natural compounds have strong antitumor activities, and its family member Ecteinasicdins743 (ET-743, Trabectedin) has been marketed in the European Union and the United States for the treatment of advanced soft tissue tumors and ovarian cancer. Because of the excellent biological activity and complex chemical structure of this kind of THIQ products, it has aroused great interest of biologists and chemists, and many synthetic chemists have paid considerable efforts to their total synthesis over the past decade. Based on this, the recent advances in the total synthesis of such THIQ alkaloids are reviewed.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Produtos Biológicos
/
Tetra-Hidroisoquinolinas
/
Alcaloides
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article