Cell-Specific Expression of Human SIRT1 by Gene Therapy Reduces Retinal Ganglion Cell Loss Induced by Elevated Intraocular Pressure.

Yue, Jipeng; Khan, Reas S; Duong, Thu T; Dine, Kimberly E; Cui, Qi N; O'Neill, Nuala; Aravand, Puya; Liu, Tehui; Chaqour, Brahim; Shindler, Kenneth S; Ross, Ahmara G

Yue, Jipeng; Khan, Reas S; Duong, Thu T; Dine, Kimberly E; Cui, Qi N; O'Neill, Nuala; Aravand, Puya; Liu, Tehui; Chaqour, Brahim; Shindler, Kenneth S; Ross, Ahmara G.

Afiliação

Yue J; University of Pennsylvania/Ophthalmology, Philadelphia, PA, USA.
Khan RS; University of Pennsylvania/Ophthalmology, Philadelphia, PA, USA.
Duong TT; Center for Advanced Retinal and Ocular Therapeutics, F. M. Kirby Center for Molecular Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Dine KE; University of Pennsylvania/Ophthalmology, Philadelphia, PA, USA.
Cui QN; Center for Advanced Retinal and Ocular Therapeutics, F. M. Kirby Center for Molecular Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
O'Neill N; University of Pennsylvania/Ophthalmology, Philadelphia, PA, USA.
Aravand P; University of Pennsylvania/Ophthalmology, Philadelphia, PA, USA.
Liu T; University of Pennsylvania/Ophthalmology, Philadelphia, PA, USA.
Chaqour B; University of Pennsylvania/Ophthalmology, Philadelphia, PA, USA.
Shindler KS; Center for Advanced Retinal and Ocular Therapeutics, F. M. Kirby Center for Molecular Ophthalmology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Ross AG; University of Pennsylvania/Ophthalmology, Philadelphia, PA, USA.

Neurotherapeutics ; 20(3): 896-907, 2023 Apr.

Article em En | MEDLINE | ID: mdl-36941497

Assuntos

Glaucoma; Hipertensão Ocular; Humanos; Camundongos; Animais; Células Ganglionares da Retina/metabolismo; Pressão Intraocular; Sirtuína 1/genética; Sirtuína 1/metabolismo; Glaucoma/genética; Glaucoma/terapia; Hipertensão Ocular/genética; Hipertensão Ocular/terapia; Terapia Genética/métodos; Modelos Animais de Doenças; Axônios/metabolismo

Palavras-chave

Adeno-associated virus; Gene therapy; Glaucoma; Neuroprotection; SIRT1

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Glaucoma / Hipertensão Ocular Limite: Animals / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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