Synthesis and Antibacterial Activity Evaluation of Imidazole Derivatives Containing 6-Methylpyridine Moiety.
Chem Biodivers
; 20(5): e202300105, 2023 May.
Article
em En
| MEDLINE
| ID: mdl-36945745
ABSTRACT
A series of 2-cyclopropyl-5-(5-(6-methylpyridin-2-yl)-2-substituted-1H-imidazol-4-yl)-6-phenylimidazo[2,1-b][1,3,4]thiadiazoles (15a-t and 16a-f) were synthesized and their antibacterial activities were evaluated. More than half of the compounds showed moderate or strong antibacterial activity. Among them, compounds 15t (MIC=1-2â
µg/mL) and 16d (MIC=0.5â
µg/mL) showed the strongest antibacterial activities. Notably, compound 16d did not exhibit cytotoxicity in HepG2 cells and did not show hemolysis like the positive control compound Gatifloxacin. The results suggest that compound 16d should be further investigated as a candidate antibacterial agent.
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Base de dados:
MEDLINE
Assunto principal:
Antibacterianos
/
Nitroimidazóis
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article