The emerging roles of the cytoskeleton in intestinal epithelium homeostasis.
Semin Cell Dev Biol
; 150-151: 23-27, 2023 12.
Article
em En
| MEDLINE
| ID: mdl-36948998
ABSTRACT
The intestinal epithelium must absorb many nutrients and water while forming a barrier that is impermeable to pathogens present in the external environment. Concurrently to fulfill this dual role, the intestinal epithelium is challenged by a rapid renewal of cells and forces resulting from digestion. Hence, intestinal homeostasis requires precise control of tissue integrity, tissue renewal, cell polarity, and force generation/transmission. In this review, we highlight the contribution of the cell cytoskeleton- actin, microtubules, and intermediate filaments- to intestinal epithelium homeostasis. With a focus on enterocytes, we first discuss the role of these networks in the formation and maintenance of cell-cell and cell-matrix junctions. Then, we cover their role in intracellular trafficking related to the apicobasal polarity of enterocytes. Finally, we report on the cytoskeletal changes that occur during tissue renewal. In conclusion, the importance of the cytoskeleton in maintaining intestinal homeostasis is emerging, and we think this field will keep evolving.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Citoesqueleto
/
Microtúbulos
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article