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Race-dependent association of clinical trial participation with improved outcomes for high-risk prostate cancer patients treated in the modern era.
Ma, Ting Martin; Feng, Felix Y; Rosenthal, Seth A; Rettig, Matthew B; Raldow, Ann C; Spratt, Daniel E; Xiang, Michael; Kishan, Amar U.
Afiliação
  • Ma TM; Department of Radiation Oncology, University of California, Los Angeles, CA, USA.
  • Feng FY; Department of Radiation Oncology, University of California San Francisco, San Francisco, CA, USA.
  • Rosenthal SA; Department of Radiation Oncology, Sutter Medical Group, Roseville, CA, USA.
  • Rettig MB; Department of Urology, University of California, Los Angeles, CA, USA.
  • Raldow AC; Department of Medicine, University of California Los Angeles, Los Angeles, CA, USA.
  • Spratt DE; Department of Radiation Oncology, University of California, Los Angeles, CA, USA.
  • Xiang M; Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University School of Medicine, Cleveland, OH, USA.
  • Kishan AU; Department of Radiation Oncology, University of California, Los Angeles, CA, USA.
Prostate Cancer Prostatic Dis ; 26(3): 625-627, 2023 09.
Article em En | MEDLINE | ID: mdl-36966268
ABSTRACT
It is unclear whether cancer patients enrolled in clinical trials have improved outcomes compared with non-study patients. We compared prostate cancer-specific mortality (PCSM) in patients in a real-world setting (SEER-Medicare database) versus on a trial (NRG/RTOG 0521). The 7-year freedom from PCSM was superior in trial patients (92.4% vs. 88.1%, sHR = 1.77 [95% CI 1.05-2.97], P = 0.03). Black trial patients had significantly superior freedom from PCSM than Black real-world patients (sHR 6.52, 95% CI 1.43-29.72, P = 0.02), which was not seen among non-Black patients. Trial patients may have improved outcomes, and racial disparities are accentuated in the real world.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Aged / Humans / Male País como assunto: America do norte Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
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PubMed Links
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata Tipo de estudo: Etiology_studies / Risk_factors_studies Limite: Aged / Humans / Male País como assunto: America do norte Idioma: En Ano de publicação: 2023 Tipo de documento: Article