Synthesis and SAR of a novel Kir6.2/SUR1 channel opener scaffold identified by HTS.
Bioorg Med Chem Lett
; 87: 129256, 2023 05 01.
Article
em En
| MEDLINE
| ID: mdl-36966977
ABSTRACT
Kir6.2/SUR1 is an ATP-regulated potassium channel that acts as an intracellular metabolic sensor, controlling insulin and appetite-stimulatory neuropeptides secretion. In this Letter, we present the SAR around a novel Kir6.2/SUR1 channel opener scaffold derived from an HTS screening campaign. New series of compounds with tractable SAR trends and favorable potencies are reported.
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MEDLINE
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Receptores de Sulfonilureias
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En
Ano de publicação:
2023
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Article