Variation in Group Composition Alters an Early-Stage Social Phenotype in hAPP-Transgenic J20 Mice.
J Alzheimers Dis
; 93(1): 211-224, 2023.
Article
em En
| MEDLINE
| ID: mdl-36970900
ABSTRACT
BACKGROUND:
Altered social behavior is one of the symptoms of Alzheimer's disease (AD) that results in social withdrawal and loneliness and provides a major burden on patients and their relatives. Furthermore, loneliness is associated with an increased risk to develop AD and related dementias.OBJECTIVE:
We aimed to investigate if altered social behavior is an early indicator of amyloid-ß (Aß) pathology in J20 mice, and if co-housing with wild type (WT) mice can positively influence this social phenotype.METHODS:
The social phenotype of group-housed mice was assessed using an automated behavioral scoring system for longitudinal recordings. Female mice were housed in a same-genotype (4 J20 or WT mice per colony) or mixed-genotype (2 J20 mice + 2 WT mice) colony. At 10 weeks of age, their behavior was assessed for five consecutive days.RESULTS:
J20 mice showed increased locomotor activity and social sniffing, and reduced social contact compared to WT mice housed in same-genotype colonies. Mixed-genotype housing reduced the social sniffing duration of J20 mice, increased social contact frequency of J20 mice, and increased nest hide by WT mice.CONCLUSION:
Thus, altered social behavior can be used as an early indicator of Aß-pathology in female J20 mice. Additionally, when co-housed with WT mice, their social sniffing phenotype is not expressed and their social contact phenotype is reduced. Our findings highlight the presence of a social phenotype in the early stages of AD and indicate a role for social environment variation in the expression of social behavior of WT and J20 mice.Palavras-chave
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Base de dados:
MEDLINE
Assunto principal:
Precursor de Proteína beta-Amiloide
/
Doença de Alzheimer
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article