Chemical constituents from the aerial parts of Rubia cordifolia L. with their NO inhibitory activity.
Nat Prod Res
; 38(5): 711-718, 2024.
Article
em En
| MEDLINE
| ID: mdl-36971058
ABSTRACT
A new naphthoquinone derivative (1) together with twenty-three known compounds (2-24), were isolated from the aerial parts of Rubia cordifolia L. Their structures were elucidated on the basis of NMR and HR-ESIMS data. Compounds 1-13 were assessed for their inhibitory effects on NO production in LPS-stimulated RAW 264.7 macrophage cells. Compounds 2-6 exhibited significant inhibitory activities with IC50 values of 21.37, 13.81, 24.56, 20.32, and 30.08 µmol·L-1, respectively.
Palavras-chave
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Naftoquinonas
/
Rubia
Limite:
Animals
Idioma:
En
Ano de publicação:
2024
Tipo de documento:
Article