Neuro-stimulation in focal epilepsy: A systematic review and meta-analysis.
Epilepsy Behav
; 142: 109182, 2023 05.
Article
em En
| MEDLINE
| ID: mdl-36972642
ABSTRACT
OBJECTIVES:
Different neurostimulation modalities are available to treat drug-resistant focal epilepsy when surgery is not an option including vagus nerve stimulation (VNS), responsive neurostimulation (RNS), and deep brain stimulation (DBS). Head-to-head comparisons of efficacy do not exist between them nor are likely to be available in the future. We performed a meta-analysis on VNS, RNS, and DBS outcomes to compare seizure reduction efficacy for focal epilepsy.METHODS:
We systematically reviewed the literature for reported seizure outcomes following implantation with VNS, RNS, and DBS in focal-onset seizures and performed a meta-analysis. Prospective or retrospective clinical studies were included.RESULTS:
Sufficient data were available at years one (n = 642, two (n = 480), and three (n = 385) for comparing the three modalities with each other. Seizure reduction for the devices at years one, two, and three respectively were RNS 66.3%, 56.0%, 68.4%; DBS- 58.4%, 57.5%, 63.8%; VNS 32.9%, 44.4%, 53.5%. Seizure reduction at year one was greater for RNS (p < 0.01) and DBS (p < 0.01) compared to VNS.CONCLUSIONS:
Our findings indicate the seizure reduction efficacy of RNS is similar to DBS, and both had greater seizure reductions compared to VNS in the first-year post-implantation, with the differences diminishing with longer-term follow-up.SIGNIFICANCE:
The results help guide neuromodulation treatment in eligible patients with drug-resistant focal epilepsy.Palavras-chave
Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Epilepsias Parciais
/
Estimulação Encefálica Profunda
/
Estimulação do Nervo Vago
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Epilepsia Resistente a Medicamentos
Tipo de estudo:
Observational_studies
/
Systematic_reviews
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article