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Genetic and non-genetic risk factors for early-onset pancreatic cancer.
Nodari, Ylenia; Gentiluomo, Manuel; Mohelnikova-Duchonova, Beatrice; Kreivenaite, Edita; Milanetto, Anna Caterina; Skieceviciene, Jurgita; Landi, Stefano; Lawlor, Rita T; Petrone, Maria Chiara; Arcidiacono, Paolo Giorgio; Lovecek, Martin; Gazouli, Maria; Bijlsma, Maarten F; Morelli, Luca; Kiudelis, Vytautas; Tacelli, Matteo; Zanette, Dalila Lucíola; Soucek, Pavel; Uzunoglu, Faik; Kaaks, Rudolf; Izbicki, Jakob; Boggi, Ugo; Pezzilli, Raffaele; Mambrini, Andrea; Pasquali, Claudio; van Laarhoven, Hanneke W; Katzke, Verena; Cavestro, Giulia Martina; Sperti, Cosimo; Loos, Martin; Latiano, Anna; Eross, Bálint; Oliverius, Martin; Johnson, Theron; Basso, Daniela; Neoptolemos, John P; Aoki, Mateus Nóbrega; Greenhalf, William; Vodicka, Pavel; Archibugi, Livia; Vanella, Giuseppe; Lucchesi, Maurizio; Talar-Wojnarowska, Renata; Jamroziak, Krzysztof; Saeedi, Mohammed Al; van Eijck, Casper H J; Kupcinskas, Juozas; Hussein, Tamás; Puzzono, Marta; Bunduc, Stefania.
Afiliação
  • Nodari Y; Department of Biology, University of Pisa, Pisa, Italy.
  • Gentiluomo M; Department of Biology, University of Pisa, Pisa, Italy.
  • Mohelnikova-Duchonova B; Department of Oncology, Faculty of Medicine and Dentistry, Palacký University, Olomouc, Czech Republic.
  • Kreivenaite E; Gastroenterology Department and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
  • Milanetto AC; Dept. of Surgery, Oncology and Gastroenterology, University of Padova Chirurgia Generale 3, Padova, Italy.
  • Skieceviciene J; Gastroenterology Department and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
  • Landi S; Department of Biology, University of Pisa, Pisa, Italy.
  • Lawlor RT; Department of Diagnostics and Public Health, and ARC-Net Research Centre, University of Verona, Verona, Italy.
  • Petrone MC; PancreatoBiliary Endoscopy and Endosonography Division, Pancreas Translational and Clinical Research Center Vita Salute San Raffaele University San Raffaele Scientific Institute, Milan, Italy.
  • Arcidiacono PG; PancreatoBiliary Endoscopy and Endosonography Division, Pancreas Translational and Clinical Research Center Vita Salute San Raffaele University San Raffaele Scientific Institute, Milan, Italy.
  • Lovecek M; Department of Surgery I, University Hospital Olomouc, Olomouc, Czech Republic.
  • Gazouli M; Laboratory of Biology, Department of Basic Medical Science, School of Medicine, National Kapodistrian University of Athens, Athens, Greece.
  • Bijlsma MF; Center for Experimental and Molecular Medicine, Laboratory for Experimental Oncology and Radiobiology, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands; Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, The Netherlands.
  • Morelli L; General Surgery Unit, Department of Translational Research and New Technologies in Medicine and Surgery, University of Pisa, Pisa, Italy.
  • Kiudelis V; Gastroenterology Department and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
  • Tacelli M; PancreatoBiliary Endoscopy and Endosonography Division, Pancreas Translational and Clinical Research Center Vita Salute San Raffaele University San Raffaele Scientific Institute, Milan, Italy.
  • Zanette DL; Laboratory for Applied Science and Technology in Health, Carlos Chagas Institute, Oswaldo Cruz Foundation (Fiocruz), Curitiba, Brazil.
  • Soucek P; Laboratory of Pharmacogenomics, Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic.
  • Uzunoglu F; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Kaaks R; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Izbicki J; Department of General, Visceral and Thoracic Surgery, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Boggi U; Divisione di Chirurgia Generale e dei Trapianti, Università di Pisa, Pisa, Italy.
  • Pezzilli R; Country Medical Association of Potenza, Potenza, Italy.
  • Mambrini A; Oncological Department, Massa Carrara Azienda USL Toscana Nord Ovest, Carrara, Italy.
  • Pasquali C; Dept. of Surgery, Oncology and Gastroenterology, University of Padova Chirurgia Generale 3, Padova, Italy.
  • van Laarhoven HW; Department of Medical Oncology, Amsterdam UMC, location University of Amsterdam, Amsterdam, The Netherlands; Imaging and Biomarkers, Cancer Center Amsterdam, Amsterdam, The Netherlands.
  • Katzke V; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Cavestro GM; Gastroenterology and Gastrointestinal Endoscopy Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
  • Sperti C; Deptartment of Surgery, Oncology and Gastroenterology, University of Padova Chirurgia Generale 1, Padova, Italy.
  • Loos M; Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany.
  • Latiano A; Division of Gastroenterology, Fondazione IRCCS "Casa Sollievo della Sofferenza" Hospital, San Giovanni Rotondo, Italy.
  • Eross B; Institute for Translational Medicine, Medical School, University of Pécs, Pécs, Hungary; Center for Translational Medicine, Semmelweis University, Budapest, Hungary; Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
  • Oliverius M; Department of General Surgery, University Hospital Kralovske Vinohrady, Third Faculty of Medicine, Charles University, Prague, Czech Republic.
  • Johnson T; Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
  • Basso D; Department of Medicine-DIMED, Laboratory Medicine-University of Padova, Padova, Italy.
  • Neoptolemos JP; Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany.
  • Aoki MN; Laboratory for Applied Science and Technology in Health, Carlos Chagas Institute, Oswaldo Cruz Foundation (Fiocruz), Curitiba, Brazil.
  • Greenhalf W; Molecular and Clinical Cancer Medicine, The University of Liverpool, Liverpool, United Kingdom.
  • Vodicka P; Department of Molecular Biology of Cancer, Institute of Experimental Medicine of the Czech Academy of Sciences, Prague, Czech Republic; Biomedical Center, Faculty of Medicine in Pilsen, Charles University, Pilsen, Czech Republic; Institute of Biology and Medical Genetics, First Faculty of Medicine,
  • Archibugi L; Digestive and Liver Disease Unit, S. Andrea Hospital, "Sapienza" University of Rome, Rome, Italy; Pancreato-Biliary Endoscopy and Endosonography Division, IRCCS San Raffaele Scientific Institute, Pancreas Translational and Clinical Research Center, Vita-Salute San Raffaele University, Milan, Italy.
  • Vanella G; Digestive and Liver Disease Unit, S. Andrea Hospital, "Sapienza" University of Rome, Rome, Italy; Pancreato-Biliary Endoscopy and Endosonography Division, IRCCS San Raffaele Scientific Institute, Pancreas Translational and Clinical Research Center, Vita-Salute San Raffaele University, Milan, Italy.
  • Lucchesi M; Oncological Department, Massa Carrara Azienda USL Toscana Nord Ovest, Carrara, Italy.
  • Talar-Wojnarowska R; Department of Digestive Tract Diseases, Medical University of Lodz, Lodz, Poland.
  • Jamroziak K; Department of Hematology, Transplantation and Internal Medicine, University Clinical Center of the Medical University of Warsaw, Warsaw, Poland.
  • Saeedi MA; Department of General, Visceral and Transplantation Surgery, University Hospital Heidelberg, Heidelberg, Germany.
  • van Eijck CHJ; Department of Surgery, Erasmus MC University Medical Center, Rotterdam, the Netherlands.
  • Kupcinskas J; Gastroenterology Department and Institute for Digestive Research, Lithuanian University of Health Sciences, Kaunas, Lithuania.
  • Hussein T; Center for Translational Medicine, Semmelweis University, Budapest, Hungary; Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
  • Puzzono M; Gastroenterology and Gastrointestinal Endoscopy Unit, IRCCS San Raffaele Scientific Institute, Vita-Salute San Raffaele University, Milan, Italy.
  • Bunduc S; Carol Davila University of Medicine and Pharmacy, Bucharest, Romania; Center for Translational Medicine, Semmelweis University, Budapest, Hungary; Division of Pancreatic Diseases, Heart and Vascular Center, Semmelweis University, Budapest, Hungary.
Dig Liver Dis ; 55(10): 1417-1425, 2023 10.
Article em En | MEDLINE | ID: mdl-36973108
ABSTRACT

BACKGROUND:

Early-onset pancreatic cancer (EOPC) represents 5-10% of all pancreatic ductal adenocarcinoma (PDAC) cases, and the etiology of this form is poorly understood. It is not clear if established PDAC risk factors have the same relevance for younger patients. This study aims to identify genetic and non-genetic risk factors specific to EOPC.

METHODS:

A genome-wide association study was performed, analysing 912 EOPC cases and 10 222 controls, divided into discovery and replication phases. Furthermore, the associations between a polygenic risk score (PRS), smoking, alcohol consumption, type 2 diabetes and PDAC risk were also assessed.

RESULTS:

Six novel SNPs were associated with EOPC risk in the discovery phase, but not in the replication phase. The PRS, smoking, and diabetes affected EOPC risk. The OR comparing current smokers to never-smokers was 2.92 (95% CI 1.69-5.04, P = 1.44 × 10-4). For diabetes, the corresponding OR was 14.95 (95% CI 3.41-65.50, P = 3.58 × 10-4).

CONCLUSION:

In conclusion, we did not identify novel genetic variants associated specifically with EOPC, and we found that established PDAC risk variants do not have a strong age-dependent effect. Furthermore, we add to the evidence pointing to the role of smoking and diabetes in EOPC.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Carcinoma Ductal Pancreático / Diabetes Mellitus Tipo 2 Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article
Texto completo
Imprimir
XML
PubMed Links
Buscar no Google

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Pancreáticas / Carcinoma Ductal Pancreático / Diabetes Mellitus Tipo 2 Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article