Mosaic Loss of Y Chromosome in White Blood Cells: Its Impact on Men's Health.

Sano, Soichi; Thel, Mark C; Walsh, Kenneth

Sano, Soichi; Thel, Mark C; Walsh, Kenneth.

Afiliação

Sano S; Department of Cardiovascular Medicine, Osaka Metropolitan University Graduate School of Medicine, Osaka, Japan.
Thel MC; Laboratory of Cardiovascular Mosaicism, National Cerebral and Cardiovascular Center, Osaka, Japan.
Walsh K; Hematovascular Biology Center, Robert M. Berne Cardiovascular Research Center, University of Virginia School of Medicine, Charlottesville, Virginia, United States.

Physiology (Bethesda) ; 38(4): 0, 2023 07 01.

Article em En | MEDLINE | ID: mdl-36976266

ABSTRACT

ABSTRACT

We present a brief introduction of loss of Y chromosome (LOY) in blood and describe the known risk factors for this condition. We then overview the associations between LOY and age-related disease traits. Finally, we discuss murine models and the potential mechanisms by which LOY contributes to disease.

Assuntos

Cromossomos Humanos Y; Saúde do Homem; Humanos; Animais; Masculino; Camundongos; Mosaicismo; Leucócitos; Fenótipo

Palavras-chave

aneuploidy; clonal hematopoiesis; fibrosis; inflammation

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Cromossomos Humanos Y / Saúde do Homem Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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