Production of nitrosamines from ephedrine, pseudoephedrine and extracts of Ephedra foliata under physiological conditions.
Cancer Lett
; 31(2): 221-6, 1986 May.
Article
em En
| MEDLINE
| ID: mdl-3697965
ABSTRACT
N-Nitrosoephedrine (NEP) and N-nitrosopseudoephedrine (NPEP) were synthesised at 5 degrees C using different concentrations of various acids. The reaction with acetic acid gave the highest yield (85%) of N-nitrosamine. Ephedrine and pseudoephedrine were reacted with nitrite under physiological conditions (37 degrees C, pH 1-3) to form NEP and NPEP. The yield of NEP, which is a known carcinogen, and NPEP were the highest (18.5%) at pH 2. Aqueous and alcoholic extracts of Ephedra foliata (100 g dry wt), nitrosated under physiological conditions, produced 0.77 mg and 8.3 mg, respectively, as total nitrosamines. This indicated the potential of the nitrosamine formation from the plant extracts specified.
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Base de dados:
MEDLINE
Assunto principal:
Plantas Medicinais
/
Extratos Vegetais
/
Efedrina
/
Nitrosaminas
Idioma:
En
Ano de publicação:
1986
Tipo de documento:
Article