Iron Deficiency and Nephrotoxic Heavy Metals: A Dangerous Interplay?
Int J Mol Sci
; 24(6)2023 Mar 10.
Article
em En
| MEDLINE
| ID: mdl-36982393
ABSTRACT
Heavy metals are common in our environment, and all individuals are exposed to them to some extent. These toxic metals have several harmful effects on the body, including the kidney, which is a very sensitive organ. Indeed, heavy metal exposure has been linked to an increased risk of chronic kidney disease (CKD) and its progression, which may be explained by the well-established nephrotoxic effects of these metals. In this hypothesis and narrative literature review, we will shed light on the potential role that another highly common problem in patients with CKD, iron deficiency, may play in the damaging effects of heavy metal exposure in this patient group. Iron deficiency has previously been linked with an increased uptake of heavy metals in the intestine due to the upregulation of iron receptors that also take up other metals. Furthermore, recent research suggests a role of iron deficiency in the retention of heavy metals in the kidney. Therefore, we hypothesize that iron deficiency plays a crucial role in the damaging effects of heavy metal exposure in patients with CKD and that iron supplementation might be a strategy to combat these detrimental processes.
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Texto completo:
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Base de dados:
MEDLINE
Assunto principal:
Metais Pesados
/
Insuficiência Renal Crônica
/
Deficiências de Ferro
Limite:
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article