Microparticles in the Development and Improvement of Pharmaceutical Formulations: An Analysis of In Vitro and In Vivo Studies.
Int J Mol Sci
; 24(6)2023 Mar 13.
Article
em En
| MEDLINE
| ID: mdl-36982517
ABSTRACT
Microparticulate systems such as microparticles, microspheres, microcapsules or any particle in a micrometer scale (usually of 1-1000 µm) are widely used as drug delivery systems, because they offer higher therapeutic and diagnostic performance compared to conventional drug delivery forms. These systems can be manufactured with many raw materials, especially polymers, most of which have been effective in improving the physicochemical properties and biological activities of active compounds. This review will focus on the in vivo and in vitro application in the last decade (2012 to 2022) of different active pharmaceutical ingredients microencapsulated in polymeric or lipid matrices, the main formulation factors (excipients and techniques) and mostly their biological activities, with the aim of introducing and discussing the potential applicability of microparticulate systems in the pharmaceutical field.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Polímeros
/
Sistemas de Liberação de Medicamentos
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article