Parthenolide Phytosomes Attenuated Gentamicin-Induced Nephrotoxicity in Rats via Activation of Sirt-1, Nrf2, OH-1, and NQO1 Axis.

Albalawi, Rawan S; Binmahfouz, Lenah S; Hareeri, Rawan H; Shaik, Rasheed A; Bagher, Amina M

Albalawi, Rawan S; Binmahfouz, Lenah S; Hareeri, Rawan H; Shaik, Rasheed A; Bagher, Amina M.

Afiliação

Albalawi RS; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Binmahfouz LS; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Hareeri RH; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Shaik RA; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.
Bagher AM; Department of Pharmacology and Toxicology, Faculty of Pharmacy, King Abdulaziz University, Jeddah 21589, Saudi Arabia.

Molecules ; 28(6)2023 Mar 17.

Article em En | MEDLINE | ID: mdl-36985711

Assuntos

Gentamicinas; Sesquiterpenos; Ratos; Animais; Gentamicinas/efeitos adversos; Fator 2 Relacionado a NF-E2/metabolismo; Fitossomas; Sirtuína 1/metabolismo; Rim; Antioxidantes/farmacologia; Sesquiterpenos/farmacologia; Sesquiterpenos/metabolismo; Estresse Oxidativo; NAD(P)H Desidrogenase (Quinona)/metabolismo

Palavras-chave

KIM-1; NFκB; Nrf2; Sirt-1; gentamicin; nephrotoxicity; parthenolide; phytosomes

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Gentamicinas Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo

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PubMed Links

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sesquiterpenos / Gentamicinas Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article