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Multimodal Radiobioconjugates of Magnetic Nanoparticles Labeled with 44Sc and 47Sc for Theranostic Application.
Ünak, Perihan; Yasakçi, Volkan; Tutun, Elif; Karatay, K Busra; Walczak, Rafal; Wawrowicz, Kamil; Zelechowska-Matysiak, Kinga; Majkowska-Pilip, Agnieszka; Bilewicz, Aleksander.
Afiliação
  • Ünak P; Department of Nuclear Applications, Institute of Nuclear Sciences, Ege University, Izmir 35100, Turkey.
  • Yasakçi V; Department of Nuclear Applications, Institute of Nuclear Sciences, Ege University, Izmir 35100, Turkey.
  • Tutun E; Department of Nuclear Applications, Institute of Nuclear Sciences, Ege University, Izmir 35100, Turkey.
  • Karatay KB; Department of Nuclear Applications, Institute of Nuclear Sciences, Ege University, Izmir 35100, Turkey.
  • Walczak R; Centre of Radiochemistry and Nuclear Chemistry, Institute of Nuclear Chemistry and Technology, Dorodna 16 St., 03-195 Warsaw, Poland.
  • Wawrowicz K; Centre of Radiochemistry and Nuclear Chemistry, Institute of Nuclear Chemistry and Technology, Dorodna 16 St., 03-195 Warsaw, Poland.
  • Zelechowska-Matysiak K; Centre of Radiochemistry and Nuclear Chemistry, Institute of Nuclear Chemistry and Technology, Dorodna 16 St., 03-195 Warsaw, Poland.
  • Majkowska-Pilip A; Centre of Radiochemistry and Nuclear Chemistry, Institute of Nuclear Chemistry and Technology, Dorodna 16 St., 03-195 Warsaw, Poland.
  • Bilewicz A; Centre of Radiochemistry and Nuclear Chemistry, Institute of Nuclear Chemistry and Technology, Dorodna 16 St., 03-195 Warsaw, Poland.
Pharmaceutics ; 15(3)2023 Mar 05.
Article em En | MEDLINE | ID: mdl-36986710
This study was performed to synthesize multimodal radiopharmaceutical designed for the diagnosis and treatment of prostate cancer. To achieve this goal, superparamagnetic iron oxide (SPIO) nanoparticles were used as a platform for targeting molecule (PSMA-617) and for complexation of two scandium radionuclides, 44Sc for PET imaging and 47Sc for radionuclide therapy. TEM and XPS images showed that the Fe3O4 NPs have a uniform cubic shape and a size from 38 to 50 nm. The Fe3O4 core are surrounded by SiO2 and an organic layer. The saturation magnetization of the SPION core was 60 emu/g. However, coating the SPIONs with silica and polyglycerol reduces the magnetization significantly. The obtained bioconjugates were labeled with 44Sc and 47Sc, with a yield higher than 97%. The radiobioconjugate exhibited high affinity and cytotoxicity toward the human prostate cancer LNCaP (PSMA+) cell line, much higher than for PC-3 (PSMA-) cells. High cytotoxicity of the radiobioconjugate was confirmed by radiotoxicity studies on LNCaP 3D spheroids. In addition, the magnetic properties of the radiobioconjugate should allow for its use in guide drug delivery driven by magnetic field gradient.
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Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Idioma: En Ano de publicação: 2023 Tipo de documento: Article