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The prognostic significance of Nectin-2 and Nectin-4 expression in glial tumors.
Dekanic, Andrea; Babarovic, Emina; Kucan Brlic, Paola; Knezic, Matija; Savic Vukovic, Anita; Mazor, Marija; Jonjic, Nives.
Afiliação
  • Dekanic A; Clinical Department of Pathology and Cytology, Clinical Hospital Center Rijeka, Kresimirova 42, 51000 Rijeka, Croatia.
  • Babarovic E; Clinical Department of Pathology and Cytology, Clinical Hospital Center Rijeka, Kresimirova 42, 51000 Rijeka, Croatia.
  • Kucan Brlic P; Center for Proteomics, Faculty of Medicine, University of Rijeka, Brace Branchetta 20, 51000 Rijeka, Croatia.
  • Knezic M; Clinical Department of Pathology and Cytology, Clinical Hospital Center Rijeka, Kresimirova 42, 51000 Rijeka, Croatia.
  • Savic Vukovic A; Clinical Department of Pathology and Cytology, Clinical Hospital Center Rijeka, Kresimirova 42, 51000 Rijeka, Croatia.
  • Mazor M; Center for Proteomics, Faculty of Medicine, University of Rijeka, Brace Branchetta 20, 51000 Rijeka, Croatia.
  • Jonjic N; Clinical Department of Pathology and Cytology, Clinical Hospital Center Rijeka, Kresimirova 42, 51000 Rijeka, Croatia. Electronic address: nives.jonjic@medri.uniri.hr.
Pathol Res Pract ; 244: 154416, 2023 Apr.
Article em En | MEDLINE | ID: mdl-36989846
Glial tumors are the most frequent neoplasms of the central nervous system in adults and despite recent advances in diagnosis and treatment of the disease, the prognosis of glioma is poor. Therefore, there is a great need to identify new prognostic factors and potential immunotherapeutic targets. Members of the Nectin family of proteins are gaining significant attention as possible diagnostic and immunotherapeutic targets in many solid tumors, but they have not been extensively investigated in glial tumors. The aim of the present study was to evaluate the expression of Nectin-2 and Nectin-4 in glial tumors of different grades, and to assess their prognostic value. The results showed heterogeneous expression of Nectin-2 and Nectin-4 in tumor cells and neuropil, with significantly higher Nectin-2 expression compared to Nectin-4, but without differences among tumor grades. In addition, the expression of Nectin-2 and Nectin-4 was associated with shorter survival times in patients with grade II/III gliomas. These results suggest that Nectin-2 and Nectin-4 expression may be used as an independent prognostic indicator for patients with II/III gliomas. This study contributes to the development of personalized care for patients with glioma and provides a basis for further research on nectin-based immunotherapy for brain tumors.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioma Tipo de estudo: Prognostic_studies Limite: Adult / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Encefálicas / Glioma Tipo de estudo: Prognostic_studies Limite: Adult / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article