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Determining impairment in the Swedish, Polish and German ECAS: the importance of adjusting for age and education.
Finsel, Julia; Winroth, Ivar; Ciecwierska, Katarzyna; Helczyk, Olga; Stenberg, Erica A; Häggström, Ann-Christin; Ludolph, Albert C; Uttner, Ingo; Semb, Olof; Pilczuk, Beata; Szejko, Natalia; Rosentul, Simona; Lulé, Dorothée; Kuzma-Kozakiewicz, Magdalena; Andersen, Peter M.
Afiliação
  • Finsel J; Department of Neurology, Ulm University, Ulm, Germany.
  • Winroth I; Department of Clinical Science, Neurosciences, Faculty of Medicine, Umeå University, Umeå, Sweden.
  • Ciecwierska K; Department of Neurology, University Clinical Centre of Medical University of Warsaw, Warsaw, Poland.
  • Helczyk O; Department of Neurology, Ulm University, Ulm, Germany.
  • Stenberg EA; Department of Clinical Science, Neurosciences, Faculty of Medicine, Umeå University, Umeå, Sweden.
  • Häggström AC; Department of Clinical Science, Neurosciences, Faculty of Medicine, Umeå University, Umeå, Sweden.
  • Ludolph AC; Department of Neurology, Ulm University, Ulm, Germany.
  • Uttner I; Department of Neurology, Ulm University, Ulm, Germany.
  • Semb O; Department of Bioethics, Medical University of Warsaw, Warsaw, Poland.
  • Pilczuk B; Department of Neurology, University Clinical Centre of Medical University of Warsaw, Warsaw, Poland.
  • Szejko N; Department of Neurology, University Clinical Centre of Medical University of Warsaw, Warsaw, Poland.
  • Rosentul S; Department of Bioethics, Medical University of Warsaw, Warsaw, Poland.
  • Lulé D; Department of Clinical Sciences, Psychiatry, Faculty of Medicine, Umeå University, Umeå, Sweden.
  • Kuzma-Kozakiewicz M; Department of Neurology, Ulm University, Ulm, Germany.
  • Andersen PM; Department of Neurology, University Clinical Centre of Medical University of Warsaw, Warsaw, Poland.
Article em En | MEDLINE | ID: mdl-36994762
Objective: Age and years of education are strong predictors of cognitive performance in several versions of the Edinburgh Cognitive and Behavioral ALS Screen (ECAS) and cutoffs for the Swedish and Polish versions are not established yet. Here we evaluated the performance of healthy subjects on the national versions of the Swedish and Polish ECAS and compared cognitive performance on three European translations of the ECAS. Methods: The ECAS performances of healthy subjects from Sweden (n = 111), Poland (n = 124) and Germany (n = 86) were compared. Based on the test results on the national versions of ECAS, age- and education-adjusted cutoffs were compared for the German, Swedish and Polish versions, respectively. Results: Age and years of education correlated with performance in the ECAS. Swedish subjects under the age of 60 years and Swedish subjects with low education level scored significantly higher in memory than the respective German and Polish subgroups. German and Polish subjects over 60 years of age performed significantly better in language than the respective Swedish subgroup. The Polish cohort in total had lower executive scores compared to the Swedish cohort, and lower than the German subjects in the higher education subgroup. Conclusions: The results highlight the importance of establishing age- and education-adjusted ECAS cutoffs not only in general, but also for seemingly similar populations of different origins. The results should be taken into account when comparing cognition data across patient populations including in drug trials where an ECAS test result is being used as an inclusion criterium or outcome measure.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos Cognitivos / Esclerose Lateral Amiotrófica Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Aged / Humans / Middle aged País como assunto: Europa Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Transtornos Cognitivos / Esclerose Lateral Amiotrófica Tipo de estudo: Diagnostic_studies / Prognostic_studies Limite: Aged / Humans / Middle aged País como assunto: Europa Idioma: En Ano de publicação: 2023 Tipo de documento: Article