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Association between triglyceride glucose-body mass index and cardiovascular outcomes in patients undergoing percutaneous coronary intervention: a retrospective study.
Cheng, Yang; Fang, Zhen; Zhang, Xinxin; Wen, Yuchen; Lu, Jiaqi; He, Shenghu; Xu, Bing.
Afiliação
  • Cheng Y; Clinical Medical College, Yangzhou University, Yangzhou, 225001, China.
  • Fang Z; The Yangzhou School of Clinical Medicine, Dalian Medical University, Dalian, 116044, China.
  • Zhang X; Clinical Medical College, Yangzhou University, Yangzhou, 225001, China.
  • Wen Y; Department of Cardiology, Northern Jiangsu People's Hospital, Yangzhou University, Yangzhou, 225001, China.
  • Lu J; Clinical Medical College, Yangzhou University, Yangzhou, 225001, China.
  • He S; Department of Cardiology, Northern Jiangsu People's Hospital, Yangzhou University, Yangzhou, 225001, China.
  • Xu B; Clinical Medical College, Yangzhou University, Yangzhou, 225001, China.
Cardiovasc Diabetol ; 22(1): 75, 2023 03 30.
Article em En | MEDLINE | ID: mdl-36997935
BACKGROUND: The triglyceride glucose-body mass index (TyG-BMI index) has been considered a reliable surrogate measure of insulin resistance; however, its ability to predict the incidence of cardiovascular disease in individuals with coronary artery disease (CAD) remains uncertain. The aim of this study was to demonstrate the correlation between the TyG-BMI index and cardiovascular incidence. METHODS: A total of 2533 consecutive participants who underwent percutaneous coronary intervention (PCI) and drug-eluting stent (DES) implantation were included. Data from 1438 patients was analyzed in the study. The endpoint was defined as a composite of acute myocardial infarction, repeat revascularization, stroke, and all-cause mortality (major adverse cardiac and cerebrovascular events, MACCEs) at 34-month follow-up. The formula for calculating the TyG-BMI index is ln [fasting triglyceride (mg/dL) × fasting blood glucose (mg/dL)/2] × BMI. RESULTS: Among the 1438 participants, 195 incident patient cases of MACCEs were ascertained. The incidence of MACCEs showed no statistically significant differences in the TyG-BMI index tertiles in the overall population. Further exploratory subgroup analysis and multivariable logistic regression analysis revealed a linear relationship between the TyG-BMI index (per 1 SD increased) and MACCEs in the elderly patients (OR = 1.22, 95% CI 1.011-1.467, p = 0.038) and in the female patients (OR = 1.33, 95% CI 1.004-1.764, p = 0.047). The addition of the TyG-BMI index to traditional risk factor models in elderly and female patients did not improve risk prediction for MACCEs. CONCLUSION: A higher TyG-BMI index was proportionally related to an increased incidence of MACCEs in the elderly or female patients. However, the inclusion of the TyG-BMI index did not provide better predictive performance for MACCEs in the elderly, specifically in female patients.
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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Stents Farmacológicos / Intervenção Coronária Percutânea Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Stents Farmacológicos / Intervenção Coronária Percutânea Tipo de estudo: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Limite: Aged / Female / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article