An oncolytic herpes simplex virus type 1 strain expressing a single-chain variable region antibody fragment against PD-1 and a PI3K inhibitor synergize to elicit antitumor immunity in ovarian cancer.

Huang, Shanying; Hu, Haiyan; Tang, Guoling; Liu, Kai; Luo, Zhihua; Zeng, Weiwei

Huang, Shanying; Hu, Haiyan; Tang, Guoling; Liu, Kai; Luo, Zhihua; Zeng, Weiwei.

Afiliação

Huang S; Inpatient Department of Gynaecology, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, No.2004 Hongli Road, Futian District, Shenzhen, Guangdong, 518028, China. lovhap@163.com.
Hu H; Inpatient Department of Gynaecology, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, No.2004 Hongli Road, Futian District, Shenzhen, Guangdong, 518028, China.
Tang G; Inpatient Department of Gynaecology, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, No.2004 Hongli Road, Futian District, Shenzhen, Guangdong, 518028, China.
Liu K; Inpatient Department of Gynaecology, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, No.2004 Hongli Road, Futian District, Shenzhen, Guangdong, 518028, China.
Luo Z; Inpatient Department of Gynaecology, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, No.2004 Hongli Road, Futian District, Shenzhen, Guangdong, 518028, China.
Zeng W; Inpatient Department of Gynaecology, Affiliated Shenzhen Maternity & Child Healthcare Hospital, Southern Medical University, No.2004 Hongli Road, Futian District, Shenzhen, Guangdong, 518028, China.

Arch Virol ; 168(4): 128, 2023 Mar 31.

Article em En | MEDLINE | ID: mdl-37002434

Assuntos

Herpesvirus Humano 1; Terapia Viral Oncolítica; Vírus Oncolíticos; Neoplasias Ovarianas; Anticorpos de Cadeia Única; Humanos; Feminino; Camundongos; Animais; Fosfatidilinositol 3-Quinases; Inibidores de Fosfoinositídeo-3 Quinase; Terapia Viral Oncolítica/métodos; Vírus Oncolíticos/genética; Anticorpos de Cadeia Única/genética; Receptor de Morte Celular Programada 1; Neoplasias Ovarianas/terapia; Neoplasias Ovarianas/patologia; Linhagem Celular Tumoral

Palavras-chave

Antitumor immunity; Oncolytic herpes simplex virus; Ovarian cancer; PI3K/AKT

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias Ovarianas / Herpesvirus Humano 1 / Vírus Oncolíticos / Terapia Viral Oncolítica / Anticorpos de Cadeia Única Tipo de estudo: Prognostic_studies Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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