UVA causes specific mutagenic DNA damage through ROS production, rather than CPD formation, in Drosophila larvae.

Negishi, Tomoe; Xing, Fang; Koike, Ryota; Iwasaki, Manami; Wakasugi, Mitsuo; Matsunaga, Tsukasa

Negishi, Tomoe; Xing, Fang; Koike, Ryota; Iwasaki, Manami; Wakasugi, Mitsuo; Matsunaga, Tsukasa.

Afiliação

Negishi T; Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan. Electronic address: tomoeisaka@gmail.com.
Xing F; Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan.
Koike R; Faculty of Pharmaceutical Sciences, Okayama University, Okayama 700-8530, Japan.
Iwasaki M; Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-1192, Japan.
Wakasugi M; Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-1192, Japan.
Matsunaga T; Institute of Medical, Pharmaceutical and Health Sciences, Kanazawa University, Kanazawa 920-1192, Japan.

Mutat Res Genet Toxicol Environ Mutagen ; 887: 503616, 2023 Apr.

Article em En | MEDLINE | ID: mdl-37003653

Assuntos

Drosophila; Mutagênicos; Animais; Espécies Reativas de Oxigênio; Drosophila/genética; Drosophila/metabolismo; Larva/genética; Ácido Úrico; Dano ao DNA; Dímeros de Pirimidina; Raios Ultravioleta/efeitos adversos; DNA

Palavras-chave

Cyclobutane pyrimidine dimer (CPD); Drosophila; Fluorescent probe; LED-UVA; Reactive oxygen species (ROS)

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Drosophila / Mutagênicos Tipo de estudo: Etiology_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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