Anticancer Activity of Methyl Protodioscin against Prostate Cancer by Modulation of Cholesterol-Associated MAPK Signaling Pathway via FOXO1 Induction.

Chen, Jie; Qin, Puyan; Tao, Zhanxia; Ding, Weijian; Yao, Yunlong; Xu, Weifang; Yin, Dengke; Tan, Song

Chen, Jie; Qin, Puyan; Tao, Zhanxia; Ding, Weijian; Yao, Yunlong; Xu, Weifang; Yin, Dengke; Tan, Song.

Afiliação

Chen J; School of Pharmacy, Anhui University of Chinese Medicine.
Qin P; School of Pharmacy, Anhui University of Chinese Medicine.
Tao Z; College of Life Science, Capital Normal University.
Ding W; School of Pharmacy, Anhui University of Chinese Medicine.
Yao Y; School of Pharmacy, Anhui University of Chinese Medicine.
Xu W; School of Pharmacy, Anhui University of Chinese Medicine.
Yin D; School of Pharmacy, Anhui University of Chinese Medicine.
Tan S; Anhui Province Key Laboratory of Research & Development of Chinese Medicine.

Biol Pharm Bull ; 46(4): 574-585, 2023.

Article em En | MEDLINE | ID: mdl-37005301

Assuntos

Neoplasias da Próstata; Saponinas; Humanos; Masculino; Animais; Camundongos; Proteínas Quinases Ativadas por Mitógeno/metabolismo; Linhagem Celular Tumoral; Transdução de Sinais; Saponinas/farmacologia; Neoplasias da Próstata/tratamento farmacológico; Neoplasias da Próstata/patologia; Proliferação de Células; Apoptose; Movimento Celular; Sistema de Sinalização das MAP Quinases; Proteína Forkhead Box O1/metabolismo

Palavras-chave

Forkhead box O1; cholesterol; lipid raft; methyl protodioscin; mitogen-activated protein kinases signaling pathway; prostate cancer

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Próstata / Saponinas Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Animals / Humans / Male Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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