NMR-tracking for 15,16-seco-cycloartane triterpenes from Cimicifuga acerina.
Phytochemistry
; 210: 113669, 2023 Jun.
Article
em En
| MEDLINE
| ID: mdl-37011706
ABSTRACT
Twelve undescribed 15,16-seco-cycloartane triterpenoids, 15,16-seco-cimiterpenes C-N, as well as five previously reported analogs were isolated by NMR-tracking methods from the rhizomes of Cimicifuga acerina (Sieb. et Zucc.) Tanaka. Among them, 15,16-seco-cimiterpenes C-N were the first 15,16-seco-cycloartane triterpenoids featuring acetal or hemiacetal structures at C-15. The chemical structures of 15,16-seco-cimiterpenes C-N were determined based on comprehensive spectroscopic analysis, chemical method, and comparison with the previous literature data. After that, all these compounds were evaluated for their lipid-lowering effects on 3T3-L1 adipocytes.15,16-seco-cimiterpene D was found to exhibit a comparable reducing lipid effect at the concentration of 50 µM, with an inhibition rate at 35.96%.
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Base de dados:
MEDLINE
Assunto principal:
Triterpenos
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Actaea
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Cimicifuga
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article