ERK1/2 inhibitors act as monovalent degraders inducing ubiquitylation and proteasome-dependent turnover of ERK2, but not ERK1.

Balmanno, Kathryn; Kidger, Andrew M; Byrne, Dominic P; Sale, Matthew J; Nassman, Nejma; Eyers, Patrick A; Cook, Simon J

Balmanno, Kathryn; Kidger, Andrew M; Byrne, Dominic P; Sale, Matthew J; Nassman, Nejma; Eyers, Patrick A; Cook, Simon J.

Afiliação

Balmanno K; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, U.K.
Kidger AM; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, U.K.
Byrne DP; Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, U.K.
Sale MJ; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, U.K.
Nassman N; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, U.K.
Eyers PA; Department of Biochemistry and Systems Biology, Institute of Systems, Molecular and Integrative Biology, University of Liverpool, Liverpool, U.K.
Cook SJ; Signalling Programme, The Babraham Institute, Babraham Research Campus, Cambridge CB22 3AT, U.K.

Biochem J ; 480(9): 587-605, 2023 05 15.

Article em En | MEDLINE | ID: mdl-37018014

Assuntos

Sistema de Sinalização das MAP Quinases; Complexo de Endopeptidases do Proteassoma; Fosforilação; Sistema de Sinalização das MAP Quinases/fisiologia; Processamento de Proteína Pós-Traducional; Ubiquitinação

Palavras-chave

ERK inhibitors; MEK; RAF; RAS; extracellular signal-regulated kinases; ubiquitin proteasome system

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Sistema de Sinalização das MAP Quinases / Complexo de Endopeptidases do Proteassoma Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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