Ursolic acid promotes microglial polarization toward the M2 phenotype via PPARÎ³ regulation of MMP2 transcription.

Wang, Yuye; Qiu, Luying; Deng, Shumin; Liu, Fang; He, Zhiyi; Li, Mengye; Wang, Yanzhe

Wang, Yuye; Qiu, Luying; Deng, Shumin; Liu, Fang; He, Zhiyi; Li, Mengye; Wang, Yanzhe.

Afiliação

Wang Y; Department of Neurology, Key Laboratory for Neurological Big Data of Liaoning Province, The First Affiliated Hospital of China Medical University, Shenyang, China; Department of Neurology, China-Japan Friendship Hospital, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing,
Qiu L; Department of Neurology, Key Laboratory for Neurological Big Data of Liaoning Province, The First Affiliated Hospital of China Medical University, Shenyang, China.
Deng S; Department of Neurology, Key Laboratory for Neurological Big Data of Liaoning Province, The First Affiliated Hospital of China Medical University, Shenyang, China.
Liu F; Department of Neurology, Key Laboratory for Neurological Big Data of Liaoning Province, The First Affiliated Hospital of China Medical University, Shenyang, China.
He Z; Department of Neurology, Key Laboratory for Neurological Big Data of Liaoning Province, The First Affiliated Hospital of China Medical University, Shenyang, China.
Li M; Department of Emergency, The First Affiliated Hospital of China Medical University, Shenyang, China.
Wang Y; Department of Neurology, Key Laboratory for Neurological Big Data of Liaoning Province, The First Affiliated Hospital of China Medical University, Shenyang, China. Electronic address: yanzhewangcmu@126.com.

Neurotoxicology ; 96: 81-91, 2023 05.

Article em En | MEDLINE | ID: mdl-37019307

Assuntos

Microglia; PPAR gama; Ratos; Animais; PPAR gama/metabolismo; PPAR gama/farmacologia; Metaloproteinase 2 da Matriz/genética; Metaloproteinase 2 da Matriz/metabolismo; Metaloproteinase 2 da Matriz/farmacologia; Metaloproteinase 9 da Matriz/genética; Metaloproteinase 9 da Matriz/metabolismo; Transdução de Sinais; Lipopolissacarídeos; Anti-Inflamatórios/farmacologia; Fenótipo; Ácido Ursólico

Palavras-chave

M2 phenotype; Matrix metalloproteinase; Microglia; Peroxisome proliferator-activated receptor gamma; Ursolic acid

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Microglia / PPAR gama Tipo de estudo: Prognostic_studies Limite: Animals Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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