Matrix stiffness regulates tumor cell intravasation through expression and ESRP1-mediated alternative splicing of MENA.

Wang, Wenjun; Taufalele, Paul V; Millet, Martial; Homsy, Kevin; Smart, Kyra; Berestesky, Emily D; Schunk, Curtis T; Rowe, Matthew M; Bordeleau, Francois; Reinhart-King, Cynthia A

Wang, Wenjun; Taufalele, Paul V; Millet, Martial; Homsy, Kevin; Smart, Kyra; Berestesky, Emily D; Schunk, Curtis T; Rowe, Matthew M; Bordeleau, Francois; Reinhart-King, Cynthia A.

Afiliação

Wang W; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.
Taufalele PV; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.
Millet M; CHU de Québec-Université Laval Research Center (Oncology Division), Québec, QC G1R 3S3, Canada; CHU de Québec-Université Laval Research Center (Oncology Division), Québec, QC G1R 3S3, Canada.
Homsy K; CHU de Québec-Université Laval Research Center (Oncology Division), Québec, QC G1R 3S3, Canada; CHU de Québec-Université Laval Research Center (Oncology Division), Québec, QC G1R 3S3, Canada.
Smart K; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.
Berestesky ED; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.
Schunk CT; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.
Rowe MM; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA.
Bordeleau F; CHU de Québec-Université Laval Research Center (Oncology Division), Québec, QC G1R 3S3, Canada; CHU de Québec-Université Laval Research Center (Oncology Division), Québec, QC G1R 3S3, Canada; Département de biologie moléculaire, de biochimie médicale et de pathologie, Université Laval, Québec, QC G1
Reinhart-King CA; Department of Biomedical Engineering, Vanderbilt University, Nashville, TN 37235, USA. Electronic address: cynthia.reinhart-king@vanderbilt.edu.

Cell Rep ; 42(4): 112338, 2023 04 25.

Article em En | MEDLINE | ID: mdl-37027295

Assuntos

Processamento Alternativo; Neoplasias da Mama; Animais; Feminino; Humanos; Camundongos; Processamento Alternativo/genética; Neoplasias da Mama/patologia; Linhagem Celular Tumoral; Proteínas de Ligação a RNA/metabolismo

Palavras-chave

CP: Cancer; ECM stiffness; ENAH; RNA splicing; epithelial splicing regulatory protein 1; trans-endothelial migration

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Neoplasias da Mama / Processamento Alternativo Limite: Animals / Female / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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