MicroRNA130a3p inhibition suppresses cervical cancer cell progression.
Oncol Rep
; 49(5)2023 May.
Article
em En
| MEDLINE
| ID: mdl-37052265
ABSTRACT
MicroRNAs (miRNAs or miRs) play essential roles in the initiation and progression of human tumors, including cervical cancer. However, the mechanisms underlying their actions in cervical cancer remain unclear. The present study aimed to evaluate the functional role of miR130a3p in cervical cancer. Cervical cancer cells were transfected with a miRNA inhibitor (antimiR130a3p) and a negative control. Adhesionindependent cell proliferation, migration and invasion were evaluated. The findings presented herein demonstrated that miR130a3p was overexpressed in HeLa, SiHa, CaSki, C4I and HCB514 cervical cancer cells. The inhibition of miR130a3p significantly reduced the proliferation, migration and invasion of cervical cancer cells. The canonical deltalike Notch1 ligand (DLL1) was identified as a possible direct target of miR103a3p. The DLL1 gene was further found to be significantly downregulated in cervical cancer tissues. On the whole, the present study demonstrates that miR130a3p contributes to the proliferation, migration and invasion of cervical cancer cells. Therefore, miR130a3p may be used as a biomarker to determine cervical cancer progression.
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Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Neoplasias do Colo do Útero
/
MicroRNAs
Tipo de estudo:
Prognostic_studies
Limite:
Female
/
Humans
Idioma:
En
Ano de publicação:
2023
Tipo de documento:
Article