Single nucleotide variants in <i>Pseudomonas aeruginosa</i> populations from sputum correlate with baseline lung function and predict disease progression in individuals with cystic fibrosis.

Saber, Morteza M; Donner, Jannik; Levade, Inès; Acosta, Nicole; Parkins, Michael D; Boyle, Brian; Levesque, Roger C; Nguyen, Dao; Shapiro, B Jesse

Single nucleotide variants in Pseudomonas aeruginosa populations from sputum correlate with baseline lung function and predict disease progression in individuals with cystic fibrosis.

Saber, Morteza M; Donner, Jannik; Levade, Inès; Acosta, Nicole; Parkins, Michael D; Boyle, Brian; Levesque, Roger C; Nguyen, Dao; Shapiro, B Jesse.

Afiliação

Saber MM; Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada.
Donner J; Department of Medicine, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.
Levade I; Department of Medicine, Research Institute of the McGill University Health Centre, Montreal, QC, Canada.
Acosta N; Department of Microbiology, Immunology and Infectious Disease, University of Calgary, Calgary, AB, Canada.
Parkins MD; Department of Microbiology, Immunology and Infectious Disease, University of Calgary, Calgary, AB, Canada.
Boyle B; Department of Medicine, University of Calgary, Calgary, AB, Canada.
Levesque RC; Integrative Systems Biology Institute, University of Laval, Québec, QC, Canada.
Nguyen D; Integrative Systems Biology Institute, University of Laval, Québec, QC, Canada.
Shapiro BJ; Department of Microbiology and Immunology, McGill University, Montreal, QC, Canada.

Microb Genom ; 9(4)2023 04.

Article em En | MEDLINE | ID: mdl-37052589

Assuntos

Fibrose Cística; Infecções por Pseudomonas; Adulto; Humanos; Fibrose Cística/complicações; Pseudomonas aeruginosa/genética; Pulmão; Infecções por Pseudomonas/etiologia; Progressão da Doença; Nucleotídeos

Palavras-chave

AmpliSeq; Pseudomonas aeruginosa; cystic fibrosis; genomics; lung function; machine learning; withinhost diversity

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Infecções por Pseudomonas / Fibrose Cística Tipo de estudo: Etiology_studies / Prognostic_studies / Risk_factors_studies Limite: Adult / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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