Short-term topiramate treatment prevents radiation-induced cytotoxic edema in preclinical models of breast-cancer brain metastasis.

Contreras-Zárate, Maria J; Alvarez-Eraso, Karen L F; Jaramillo-Gómez, Jenny A; Littrell, Zachary; Tsuji, Nikki; Ormond, D Ryan; Karam, Sana D; Kabos, Peter; Cittelly, Diana M

Contreras-Zárate, Maria J; Alvarez-Eraso, Karen L F; Jaramillo-Gómez, Jenny A; Littrell, Zachary; Tsuji, Nikki; Ormond, D Ryan; Karam, Sana D; Kabos, Peter; Cittelly, Diana M.

Afiliação

Contreras-Zárate MJ; Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Alvarez-Eraso KLF; Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Jaramillo-Gómez JA; Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Littrell Z; Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Tsuji N; Office of Laboratory Animal Resources, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Ormond DR; Department of Neurosurgery, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Karam SD; Department of Radiation Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Kabos P; Department of Medicine, Division of Medical Oncology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Cittelly DM; Department of Pathology, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.

Neuro Oncol ; 25(10): 1802-1814, 2023 10 03.

Article em En | MEDLINE | ID: mdl-37053041

Assuntos

Edema Encefálico; Neoplasias Encefálicas; Neoplasias da Mama; Humanos; Feminino; Edema Encefálico/tratamento farmacológico; Edema Encefálico/etiologia; Edema Encefálico/prevenção & controle; Topiramato/farmacologia; Topiramato/metabolismo; Edema/complicações; Edema/metabolismo; Edema/patologia; Encéfalo/patologia; Neoplasias Encefálicas/tratamento farmacológico; Neoplasias Encefálicas/radioterapia; Neoplasias Encefálicas/complicações; Aquaporina 4/genética; Aquaporina 4/metabolismo; Astrócitos/metabolismo; Neoplasias da Mama/tratamento farmacológico; Neoplasias da Mama/radioterapia

Palavras-chave

Aquaporin 4; Brain Edema; Brain metastasis; Brain radiation; Cytotoxic Edema; Topiramate

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Texto completo: 1 Base de dados: MEDLINE Assunto principal: Edema Encefálico / Neoplasias Encefálicas / Neoplasias da Mama Tipo de estudo: Etiology_studies Limite: Female / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

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