Your browser doesn't support javascript.
loading
Proactive Glucose Screening Tool Effective for Time-sensitive Identification of Hyperglycemia in Childhood Cancer Patients.
Hill, Rachel; Hamby, Tyler; Levitt, Mike; Siebert, Garland; Diaz, Maranda; Mohamed, Ashraf.
Afiliação
  • Hill R; Department of Pediatric Hematology/Oncology Fort Worth, Texas.
  • Hamby T; Department of Research Operations, Cook Children's Health Care System Fort Worth, Texas.
  • Levitt M; Texas College of Osteopathic Medicine, University of North Texas Health Science Center.
  • Siebert G; Texas College of Osteopathic Medicine, University of North Texas Health Science Center.
  • Diaz M; Texas College of Osteopathic Medicine, University of North Texas Health Science Center.
  • Mohamed A; Department of Pediatric Hematology/Oncology Fort Worth, Texas.
J Pediatr Hematol Oncol ; 45(6): e695-e701, 2023 08 01.
Article em En | MEDLINE | ID: mdl-37053507
Approximately 4% to 35% of pediatric patients undergoing treatment for acute lymphoblastic leukemia (ALL) and lymphoblastic lymphoma (LLy) develop drug-induced hyperglycemia. Though hyperglycemia is associated with poor outcomes, no guidelines for identifying drug-induced hyperglycemia currently exist, and the time course for developing hyperglycemia remains relatively uncharacterized after induction therapy. The present study evaluated a hyperglycemia screening protocol that was implemented to identify hyperglycemia more promptly, examined predictors of hyperglycemia during ALL and LLy therapy, and described the timeline for developing hyperglycemia. A retrospective review of 154 patients diagnosed with ALL or LLy at Cook Children's Medical Center between March 2018 and April 2022 was performed. Predictors of hyperglycemia were examined with Cox regression. The hyperglycemia screening protocol was ordered for 88 (57%) patients. Fifty-four (35%) patients developed hyperglycemia. In multivariate analyses, age 10 years or older (hazard ratio = 2.50, P = 0.007) and weight loss (vs gain) during induction (hazard ratio = 3.39, P < 0.05) were associated with hyperglycemia. The present study identified a population of patients at risk of developing hyperglycemia and identifies strategies for hyperglycemia screening. In addition, the present study showed that some patients developed hyperglycemia after induction therapy, which highlights the importance of continued blood glucose monitoring in at-risk patients. Implications and suggestions for further research are discussed.
Assuntos

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras / Hiperglicemia Tipo de estudo: Diagnostic_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Child / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article

Texto completo: 1 Base de dados: MEDLINE Assunto principal: Leucemia-Linfoma Linfoblástico de Células Precursoras / Hiperglicemia Tipo de estudo: Diagnostic_studies / Guideline / Observational_studies / Prognostic_studies / Risk_factors_studies / Screening_studies Limite: Child / Humans Idioma: En Ano de publicação: 2023 Tipo de documento: Article